Featured Research

from universities, journals, and other organizations

Add An 'E' For 'Evolving' To The Alphabet For Identifying Melanoma

Date:
December 15, 2004
Source:
New York University Medical Center And School Of Medicine
Summary:
One more letter should be added to the alphabetic list of warning signs of melanoma, a potentially deadly skin cancer, according to a group of NYU School of Medicine dermatologists and their Australian colleagues. Based on a review of the medical literature, they recommend adding the letter "E" -- for "evolving" -- to the first four letters of the alphabet that are already used widely to help physicians and adults identify suspicious moles on the skin.

One more letter should be added to the alphabetic list of warning signs of melanoma, a potentially deadly skin cancer, according to a group of NYU School of Medicine dermatologists and their Australian colleagues. Based on a review of the medical literature, they recommend adding the letter "E" -- for "evolving" -- to the first four letters of the alphabet that are already used widely to help physicians and adults identify suspicious moles on the skin.

Their report is published in the Dec. 8, 2004, issue of the Journal of the American Medical Association (JAMA).

Almost 20 years ago, a group of NYU dermatologists introduced the ABCD acronym for recognizing growths on the skin that could be early melanomas. They devised the rule based on many years of clinical experience, which taught them that early melanomas can be identified by their asymmetry, uneven borders, colors, and size.

The warning signs are: "A" for asymmetry; one half of a mole doesn't match the other half; "B" for border irregularity; the edges of a mole are ragged, notched or blurred; "C" for color; a non-uniform mixture of brown, black, red, white, or blue; and "D" for diameter greater than 6 millimeters, the size of a pencil eraser.

The ABCD rule has been helpful in identifying early melanoma. But now the original group of NYU dermatologists who devised the rule, along with some of their younger colleagues, recommends expanding the rule to recognize that early melanomas frequently change in appearance. This is especially true for a type of melanoma called nodular that doesn't fit neatly into the ABCD criteria, explains David Polsky, M.D., Ph.D., a dermatologist and one of the authors of the new report. Dr. Polsky is Associate Director of the NYU Department of Dermatology's Pigmented Lesions Section.

Nodular melanoma accounts for 10 to 15 percent of all melanomas. One of four basic types of melanomas, the nodular form is the most aggressive. But it frequently doesn't look suspicious, notes Dr. Polsky, because it may not have the ABC features of early melanomas. However, there are many reports in the medical literature that highlight the changing nature of these lesions, which is the most important clue to their diagnosis.

In a study of 125 patients cited in the JAMA report, for example, 78 percent of patients with nodular melanoma noted some kind of a change in the appearance of their lesion. Patients with other forms of melanoma in the study also noted a change the appearance of their lesion. Moreover, in another cited study of 169 pigmented lesions, dermatologists noted that the lesions that had changed were at least four times more likely to be melanoma than the lesions that did not change.

"An evolving lesion is one which is changing in terms of the five S's -- size, shape, symptoms such as itching or tenderness, surface bleeding, or shades of color," says Dr. Polsky. "Essentially, a lesion that significantly changes is a concerning lesion."

The incidence of melanoma continues to rise. This year it is expected to strike 55,100 people in the United States, and some 7,910 people with the disease are expected to die, according to the American Cancer Society. Excessive exposure to sunlight, a fair complexion, a family history of melanoma, and numerous moles, among other factors, place people at higher risk for developing the disease. With early detection and prompt treatment, however, melanoma is highly curable.

###

The authors of the JAMA study are: Naheed R. Abbasi, MPH, MD, Darrell S. Rigel MD, Robert J Friedman, MD, Iman Osman, MD, Alfred W. Kopf, MD, and Dr. Polsky, from the Ronald O. Perelman Department of Dermatology at NYU School of Medicine; and Helen M. Shaw, PhD, and William H. McCarthy FRACS, Med, from the Sydney Melanoma Unit, Royal Prince Alfred Hospital.

The JAMA study was supported in part by a grant from the National Institutes of Health.


Story Source:

The above story is based on materials provided by New York University Medical Center And School Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

New York University Medical Center And School Of Medicine. "Add An 'E' For 'Evolving' To The Alphabet For Identifying Melanoma." ScienceDaily. ScienceDaily, 15 December 2004. <www.sciencedaily.com/releases/2004/12/041208085657.htm>.
New York University Medical Center And School Of Medicine. (2004, December 15). Add An 'E' For 'Evolving' To The Alphabet For Identifying Melanoma. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2004/12/041208085657.htm
New York University Medical Center And School Of Medicine. "Add An 'E' For 'Evolving' To The Alphabet For Identifying Melanoma." ScienceDaily. www.sciencedaily.com/releases/2004/12/041208085657.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins