Featured Research

from universities, journals, and other organizations

Heart-stopping Antibodies

Date:
January 20, 2005
Source:
Journal Of Experimental Medicine
Summary:
The immune system uses antibodies to target foreign, "non-self" proteins and cells. Autoimmune antibodies, by contrast, attack the body's own cells, and those circulating in women with lupus and other autoimmune diseases can also cross the placenta and cause congenital heart block in the fetus. Scientists in Sweden now show how these antibodies cause heart cells to become paralyzed and eventually die, according to a study in the January 3rd issue of The Journal of Experimental Medicine.

The immune system uses antibodies to target foreign, "non-self" proteins and cells. Autoimmune antibodies, by contrast, attack the body's own cells, and those circulating in women with lupus and other autoimmune diseases can also cross the placenta and cause congenital heart block in the fetus. Scientists in Sweden now show how these antibodies cause heart cells to become paralyzed and eventually die, according to a study in the January 3rd issue of The Journal of Experimental Medicine.

Related Articles


Autoantibodies had been implicated as a cause of congenital heart block in the past, but nobody knew how they were working. This study shows that the antibodies bind to heart cells and disrupt the proper fluctuations of calcium ions that allow the cell to contract, causing a toxic build up of calcium which triggers the death of the cell.

It is not known what protein on the cell surface these antibodies are binding to, nor is it clear how these antibodies are disrupting the calcium fluctuations that are required for the heart cells to contract. The authors are actively searching for the binding target of these antibodies. Meanwhile, they hope that their success in narrowing down the identity of the responsible antibodies will provide a new way to identify women who are most at risk for having children with congenital heart block.


Story Source:

The above story is based on materials provided by Journal Of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of Experimental Medicine. "Heart-stopping Antibodies." ScienceDaily. ScienceDaily, 20 January 2005. <www.sciencedaily.com/releases/2005/01/050111124654.htm>.
Journal Of Experimental Medicine. (2005, January 20). Heart-stopping Antibodies. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2005/01/050111124654.htm
Journal Of Experimental Medicine. "Heart-stopping Antibodies." ScienceDaily. www.sciencedaily.com/releases/2005/01/050111124654.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins