Featured Research

from universities, journals, and other organizations

Genetic Regions Influencing Male Sexual Orientation Identified

Date:
January 31, 2005
Source:
University Of Illinois At Chicago
Summary:
In the first-ever study combing the entire human genome for genetic determinants of male sexual orientation, a University of Illinois at Chicago researcher has identified several areas that appear to influence whether a man is heterosexual or gay.

In the first-ever study combing the entire human genome for genetic determinants of male sexual orientation, a University of Illinois at Chicago researcher has identified several areas that appear to influence whether a man is heterosexual or gay.

The study, which is currently available online, will be published in the March issue of the biomedical journal Human Genetics.

UIC's Brian Mustanski, working with colleagues at the National Institutes of Health, found stretches of DNA that appeared to be linked to sexual orientation on three different chromosomes in the nucleus of cells of the human male.

"There is no one 'gay' gene," said Mustanski, a psychologist in the UIC department of psychiatry and lead author of the study. "Sexual orientation is a complex trait, so it's not surprising that we found several DNA regions involved in its expression."

"Our best guess is that multiple genes, potentially interacting with environmental influences, explain differences in sexual orientation."

The genomes of 456 men from 146 families with two or more gay brothers were analyzed.

While earlier studies had focused solely on the X chromosome, one of the two sex chromosomes, the present study examined all 22 pairs of non-sex chromosomes in addition to the X chromosome. The other sex chromosome, called Y, was not explored because it is not believed to contain many genes.

Identical stretches of DNA on three chromosomes -- chromosomes 7, 8 and 10 -- were found to be shared in about 60 percent of the gay brothers in the study, compared to about 50 percent expected by chance. The region on chromosome 10 correlated with sexual orientation only if it was inherited from the mother.

"Our study helps to establish that genes play an important role in determining whether a man is gay or heterosexual," said Mustanski. "The next steps will be to see if these findings can be confirmed and to identify the particular genes within these newly discovered chromosomal sequences that are linked to sexual orientation."

###

Other researchers involved in the study were Dean Hamer, at the National Institutes of Health; Nicholas Schork and Caroline Nievergelt, at the University of California at San Diego; Michael DuPree, at Pennsylvania State University; and Sven Bocklandt, at the University of California at Los Angeles.

The study was supported in part by grants from the National Science Foundation and the National Institutes of Health.

UIC ranks among the nation's top 50 universities in federal research funding and is Chicago's largest university with 25,000 students, 12,000 faculty and staff, 15 colleges and the state's major public medical center. A hallmark of the campus is the Great Cities Commitment, through which UIC faculty, students and staff engage with community, corporate, foundation and government partners in hundreds of programs to improve the quality of life in metropolitan areas around the world.

For more information about UIC, visit http://www.uic.edu.


Story Source:

The above story is based on materials provided by University Of Illinois At Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Chicago. "Genetic Regions Influencing Male Sexual Orientation Identified." ScienceDaily. ScienceDaily, 31 January 2005. <www.sciencedaily.com/releases/2005/01/050128221107.htm>.
University Of Illinois At Chicago. (2005, January 31). Genetic Regions Influencing Male Sexual Orientation Identified. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2005/01/050128221107.htm
University Of Illinois At Chicago. "Genetic Regions Influencing Male Sexual Orientation Identified." ScienceDaily. www.sciencedaily.com/releases/2005/01/050128221107.htm (accessed September 22, 2014).

Share This



More Mind & Brain News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Food Addiction Might Be Caused By PTSD

Food Addiction Might Be Caused By PTSD

Newsy (Sep. 18, 2014) New research shows that women who suffer from PTSD are three times more likely to develop a food addiction. Video provided by Newsy
Powered by NewsLook.com
Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins