Featured Research

from universities, journals, and other organizations

Cooling Lessens Brain Damage In Sick Newborn Babies

Date:
January 30, 2005
Source:
University Of Bristol
Summary:
Cooling the brains of babies deprived of oxygen at birth can reduce the risk of brain damage and cerebral palsy, according to an international study published in the Lancet on-line.

Baby wearing cap.
Credit: Photo courtesy of University Of Bristol

Cooling the brains of babies deprived of oxygen at birth can reduce the risk of brain damage and cerebral palsy, according to an international study published today (January 28) in the Lancet on-line.

Related Articles


To achieve cooling, the body temperature of babies in the trial was lowered by 3-4 degrees for 72 hours after birth using a water-filled cap.

The research was undertaken in hospitals in North America, New Zealand and the UK, and the UK arm of the trial was carried out in University College London Hospital, the University of Bristol at St Michael's and Southmead Hospitals, and Imperial College London at Hammersmith Hospital.

Babies were recruited if there was evidence that the infant had received an inadequate supply of oxygen to the brain during delivery, and when electrical activity from the brain indicated a high risk of brain injury.

The trial, which was supported by Olympic Medical from Seattle, USA indicates that, for some babies, cooling can significantly reduce brain damage. "This demonstrates for the first time that treatment may be possible for babies who suffer oxygen deprivation at birth", comments Professor Marianne Thoresen from Bristol University. Most of the English babies were treated in the Bristol hospitals.

It was discovered some years ago that when the brain is starved of oxygen at birth damage does not occur immediately; instead, as Professor John Wyatt of University College London points out, "a chemical cascade is triggered leading to brain damage hours or days afterwards".

The cooling study results from a long series of studies begun a decade ago when the UK researchers started to work on the problem together with a group from the University of Auckland in New Zealand. In experiments they found that cooling prevented the chemical cascade from causing permanent brain damage, and developed the discovery to the point where the treatment could be tested in babies.

"The success of this long scientific collaboration is a great example of UK institutions working together to be international leaders, able to collaborate effectively and fruitfully with researchers around the world" comments Professor David Edwards from Imperial College.

However, Bristol researcher Professor Andrew Whitelaw points out that: 'We need to get further information on the timing and methods of cooling, as well as which babies are most suitable for treatment, before cooling becomes the standard of care for oxygen deprived babies".

###

Imperial College and Bristol groups are currently teamed up with other researchers from the UK in the Total Body Hypothermia or 'TOBY' Trial funded by the Medical Research Council. "The TOBY trial will determine whether this simpler form of cooling has a beneficial effect, and could bring routine treatment a step closer", said Principal Investigator Dr Denis Azzopardi.


Story Source:

The above story is based on materials provided by University Of Bristol. Note: Materials may be edited for content and length.


Cite This Page:

University Of Bristol. "Cooling Lessens Brain Damage In Sick Newborn Babies." ScienceDaily. ScienceDaily, 30 January 2005. <www.sciencedaily.com/releases/2005/01/050128223639.htm>.
University Of Bristol. (2005, January 30). Cooling Lessens Brain Damage In Sick Newborn Babies. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2005/01/050128223639.htm
University Of Bristol. "Cooling Lessens Brain Damage In Sick Newborn Babies." ScienceDaily. www.sciencedaily.com/releases/2005/01/050128223639.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins