Featured Research

from universities, journals, and other organizations

Cooling Lessens Brain Damage In Sick Newborn Babies

Date:
January 30, 2005
Source:
University Of Bristol
Summary:
Cooling the brains of babies deprived of oxygen at birth can reduce the risk of brain damage and cerebral palsy, according to an international study published in the Lancet on-line.

Baby wearing cap.
Credit: Photo courtesy of University Of Bristol

Cooling the brains of babies deprived of oxygen at birth can reduce the risk of brain damage and cerebral palsy, according to an international study published today (January 28) in the Lancet on-line.

Related Articles


To achieve cooling, the body temperature of babies in the trial was lowered by 3-4 degrees for 72 hours after birth using a water-filled cap.

The research was undertaken in hospitals in North America, New Zealand and the UK, and the UK arm of the trial was carried out in University College London Hospital, the University of Bristol at St Michael's and Southmead Hospitals, and Imperial College London at Hammersmith Hospital.

Babies were recruited if there was evidence that the infant had received an inadequate supply of oxygen to the brain during delivery, and when electrical activity from the brain indicated a high risk of brain injury.

The trial, which was supported by Olympic Medical from Seattle, USA indicates that, for some babies, cooling can significantly reduce brain damage. "This demonstrates for the first time that treatment may be possible for babies who suffer oxygen deprivation at birth", comments Professor Marianne Thoresen from Bristol University. Most of the English babies were treated in the Bristol hospitals.

It was discovered some years ago that when the brain is starved of oxygen at birth damage does not occur immediately; instead, as Professor John Wyatt of University College London points out, "a chemical cascade is triggered leading to brain damage hours or days afterwards".

The cooling study results from a long series of studies begun a decade ago when the UK researchers started to work on the problem together with a group from the University of Auckland in New Zealand. In experiments they found that cooling prevented the chemical cascade from causing permanent brain damage, and developed the discovery to the point where the treatment could be tested in babies.

"The success of this long scientific collaboration is a great example of UK institutions working together to be international leaders, able to collaborate effectively and fruitfully with researchers around the world" comments Professor David Edwards from Imperial College.

However, Bristol researcher Professor Andrew Whitelaw points out that: 'We need to get further information on the timing and methods of cooling, as well as which babies are most suitable for treatment, before cooling becomes the standard of care for oxygen deprived babies".

###

Imperial College and Bristol groups are currently teamed up with other researchers from the UK in the Total Body Hypothermia or 'TOBY' Trial funded by the Medical Research Council. "The TOBY trial will determine whether this simpler form of cooling has a beneficial effect, and could bring routine treatment a step closer", said Principal Investigator Dr Denis Azzopardi.


Story Source:

The above story is based on materials provided by University Of Bristol. Note: Materials may be edited for content and length.


Cite This Page:

University Of Bristol. "Cooling Lessens Brain Damage In Sick Newborn Babies." ScienceDaily. ScienceDaily, 30 January 2005. <www.sciencedaily.com/releases/2005/01/050128223639.htm>.
University Of Bristol. (2005, January 30). Cooling Lessens Brain Damage In Sick Newborn Babies. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2005/01/050128223639.htm
University Of Bristol. "Cooling Lessens Brain Damage In Sick Newborn Babies." ScienceDaily. www.sciencedaily.com/releases/2005/01/050128223639.htm (accessed November 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Ebola Crisis Affecting US Adoptions

Ebola Crisis Affecting US Adoptions

AP (Nov. 20, 2014) The Sanborn family had hoped they'd be able to bring home their 5-year-old adopted son from Liberia by now. But Ebola has forced them to wait. The boy is just one of thousands of orphans in West Africa who've been impacted by the deadly virus. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins