Featured Research

from universities, journals, and other organizations

Cooling Lessens Brain Damage In Sick Newborn Babies

Date:
January 30, 2005
Source:
University Of Bristol
Summary:
Cooling the brains of babies deprived of oxygen at birth can reduce the risk of brain damage and cerebral palsy, according to an international study published in the Lancet on-line.

Baby wearing cap.
Credit: Photo courtesy of University Of Bristol

Cooling the brains of babies deprived of oxygen at birth can reduce the risk of brain damage and cerebral palsy, according to an international study published today (January 28) in the Lancet on-line.

To achieve cooling, the body temperature of babies in the trial was lowered by 3-4 degrees for 72 hours after birth using a water-filled cap.

The research was undertaken in hospitals in North America, New Zealand and the UK, and the UK arm of the trial was carried out in University College London Hospital, the University of Bristol at St Michael's and Southmead Hospitals, and Imperial College London at Hammersmith Hospital.

Babies were recruited if there was evidence that the infant had received an inadequate supply of oxygen to the brain during delivery, and when electrical activity from the brain indicated a high risk of brain injury.

The trial, which was supported by Olympic Medical from Seattle, USA indicates that, for some babies, cooling can significantly reduce brain damage. "This demonstrates for the first time that treatment may be possible for babies who suffer oxygen deprivation at birth", comments Professor Marianne Thoresen from Bristol University. Most of the English babies were treated in the Bristol hospitals.

It was discovered some years ago that when the brain is starved of oxygen at birth damage does not occur immediately; instead, as Professor John Wyatt of University College London points out, "a chemical cascade is triggered leading to brain damage hours or days afterwards".

The cooling study results from a long series of studies begun a decade ago when the UK researchers started to work on the problem together with a group from the University of Auckland in New Zealand. In experiments they found that cooling prevented the chemical cascade from causing permanent brain damage, and developed the discovery to the point where the treatment could be tested in babies.

"The success of this long scientific collaboration is a great example of UK institutions working together to be international leaders, able to collaborate effectively and fruitfully with researchers around the world" comments Professor David Edwards from Imperial College.

However, Bristol researcher Professor Andrew Whitelaw points out that: 'We need to get further information on the timing and methods of cooling, as well as which babies are most suitable for treatment, before cooling becomes the standard of care for oxygen deprived babies".

###

Imperial College and Bristol groups are currently teamed up with other researchers from the UK in the Total Body Hypothermia or 'TOBY' Trial funded by the Medical Research Council. "The TOBY trial will determine whether this simpler form of cooling has a beneficial effect, and could bring routine treatment a step closer", said Principal Investigator Dr Denis Azzopardi.


Story Source:

The above story is based on materials provided by University Of Bristol. Note: Materials may be edited for content and length.


Cite This Page:

University Of Bristol. "Cooling Lessens Brain Damage In Sick Newborn Babies." ScienceDaily. ScienceDaily, 30 January 2005. <www.sciencedaily.com/releases/2005/01/050128223639.htm>.
University Of Bristol. (2005, January 30). Cooling Lessens Brain Damage In Sick Newborn Babies. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2005/01/050128223639.htm
University Of Bristol. "Cooling Lessens Brain Damage In Sick Newborn Babies." ScienceDaily. www.sciencedaily.com/releases/2005/01/050128223639.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins