Featured Research

from universities, journals, and other organizations

Drugs Used To Treat Alzheimer's In Nursing Homes Are Worsening Sufferers' Illness

Date:
March 9, 2005
Source:
British Medical Journal
Summary:
Quetiapine, a drug commonly used in nursing homes to treat agitation and related symptoms in people with Alzheimers' disease actually worsens patients' illness, speeding up their rate of decline significantly, says a paper published on bmj.com.

February 17, 2005 -- Quetiapine, a drug commonly used in nursing homes to treat agitation and related symptoms in people with Alzheimers' disease actually worsens patients' illness, speeding up their rate of decline significantly, says a paper published on bmj.com today.

Antipsychotic drugs are used in up to 45% of nursing homes to treat agitation, a common and distressing symptom of dementia (a catch-all term for diseases such as Alzhimer's.)

Researchers found that, when given a placebo as treatment for these symptoms, patients showed little change. But those patients given the commonly used antipsychotic drug quetiapine showed a marked worsening in the condition with marked deterioration of memory and other higher brain functions (cognitive decline).

This is particularly significant as quetiapine had been regarded as one of the safer of the antipsychotic drugs available, say the authors.

The study looked at 93 patients with dementia across the north east of England over six months. Those in the study taking quetiapine experienced a doubling in cognitive decline compared with the control group who had been given placebo. Those taking another antipsychotic in the trial, rivatigmine, showed little or no worsening of their illness - but no improvement in symptoms above the placebo group.

There have been concerns about the safety of the two most commonly used antipsychotic drugs in people with dementia, risperidone and olanzapine, because of increased risk of stroke, say the authors. The current study highlights considerable concern regarding the safety of quetiapine, and suggest that quetipaine is not a viable alternative to these medications.

This study has vital implications for the treatment of patients with dementia, argue the authors. Quetiapine should not be used instead of other drugs for alleviating their symptoms, and these findings highlight concerns over long term use of antipsychotics in these patients.


Story Source:

The above story is based on materials provided by British Medical Journal. Note: Materials may be edited for content and length.


Cite This Page:

British Medical Journal. "Drugs Used To Treat Alzheimer's In Nursing Homes Are Worsening Sufferers' Illness." ScienceDaily. ScienceDaily, 9 March 2005. <www.sciencedaily.com/releases/2005/02/050223141718.htm>.
British Medical Journal. (2005, March 9). Drugs Used To Treat Alzheimer's In Nursing Homes Are Worsening Sufferers' Illness. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2005/02/050223141718.htm
British Medical Journal. "Drugs Used To Treat Alzheimer's In Nursing Homes Are Worsening Sufferers' Illness." ScienceDaily. www.sciencedaily.com/releases/2005/02/050223141718.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins