Featured Research

from universities, journals, and other organizations

Dysentery Uses 'Sword And Shield' To Cause Infection

Date:
March 3, 2005
Source:
Imperial College London
Summary:
Scientists have found that the bacterium that causes dysentery uses a 'sword and shield' approach to cause infection. According to research published today in Science, the team from Imperial College London and Institut Pasteur, Paris, found that shigella, the bacteria which causes dysentery, is able to invade cells, while stopping any response from the immune system.

Shigella bacterium entering a cell. (Picture: Philippe Sansonetti)

Scientists have found that the bacterium that causes dysentery uses a 'sword and shield' approach to cause infection.

Related Articles


According to research published today in Science, the team from Imperial College London and Institut Pasteur, Paris, found that shigella, the bacteria which causes dysentery, is able to invade cells, while stopping any response from the immune system.

They found that shigella was able to infect cells by using a secretion system to inject proteins into human cells, (the sword), while lipopolysaccharide (LPS) on the surface of the bacteria acts as a shield to protect the dysentery bacterium from being destroyed by the body's immune system.

Dr Christoph Tang, from Imperial College London, and one of the researchers, comments: "This is the first description of bacteria able to use this 'sword and shield' approach, showing how dysentery is able to infect the body so effectively. We have shown why the bacteria can avoid being destroyed by the body's immune responses through the expression of a molecule that acts as a shield on its surface."

The researchers found that shigella, the bacteria causing dysentery uses a Type III secretion system to inject proteins into human cells. This causes the cells to become inflamed, resulting in symptoms of dysentery, such as bloody diarrhoea. At the same time, the LPS chains on the surface of the bacteria are shortened. This allows the needles to inject proteins, while protecting the bacteria from being destroyed by the immune system.

Dr Tang adds: "This discovery greatly expands our understanding of how bacteria are sometimes able to evolve although it is unlikely to result in new treatments or vaccines for dysentery. In this case, the dysentery bacteria has evolved into a highly effective and dangerous infection."


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Dysentery Uses 'Sword And Shield' To Cause Infection." ScienceDaily. ScienceDaily, 3 March 2005. <www.sciencedaily.com/releases/2005/02/050228123230.htm>.
Imperial College London. (2005, March 3). Dysentery Uses 'Sword And Shield' To Cause Infection. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2005/02/050228123230.htm
Imperial College London. "Dysentery Uses 'Sword And Shield' To Cause Infection." ScienceDaily. www.sciencedaily.com/releases/2005/02/050228123230.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins