Featured Research

from universities, journals, and other organizations

Analysis Shows Drug Could Save Lives From Prostate Cancer

Date:
March 16, 2005
Source:
John Wiley & Sons, Inc.
Summary:
A new analysis shows the drug finasteride will save lives if given to men to prevent prostate cancer.

A new analysis shows the drug finasteride will save lives if given to men to prevent prostate cancer. Published in the April 1, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society, the new analysis of data from the Prostate Cancer Prevention Trial (PCPT), says that any possible increase in the incidence of higher-grade tumors would be more than offset by an overall reduction in the number of prostate cancer cases in the general population.

Related Articles


The recent results from the PCPT represent a milestone in cancer research, showing that prostate cancer could be prevented through chemoprevention. The study found the commonly used drug finasteride reduced the incidence of prostate cancer by 24.8 percent compared to a placebo. However, a possible increase in the number of high-grade tumors in the trial prompted many to question whether any benefits of the drug would be offset by an increase in mortality related to the higher-grade tumors. No difference in mortality was seen during the 7 years of PCPT.

To explore the problem, Joseph M. Unger, M.S. and a team of researchers from the Southwest Oncology Group Statistical Center at the Fred Hutchinson Cancer Research Center in Seattle, WA analyzed Surveillance, Epidemiology, and End Results (SEER) registry data and applied the results from the PCPT.

The results showed a net reduction in person-years saved over ten years using finasteride even after taking into account an increase in high-grade cancers. Using PCPT's 24.8 percent reduction in new cases, the drug would save 316,760 person-years over ten years. An absolute increase in 6.9 percent of cases with high-grade disease (the difference seen in the PCPT) would still mean 262,567 person-years saved.

Based on this model, the authors conclude, "even if finasteride is found to potentiate the growth of high-grade tumors, this analysis shows that the potential detrimental effects of an increased rate of cases with high grade Gleason score would be substantially outweighed by a reduction in incidence."

###

Article: "Estimated Impact of the Prostate Cancer Prevention Trial on Population Mortality," Joseph M. Unger, Ian M. Thompson, Jr., Michael LeBlanc, John J. Crowley, Phyllis J. Goodman, Leslie G. Ford, Charles A. Coltman, Jr., CANCER; Published Online: February 28, 2004 (DOI: 10.1002/cncr.20919); Print Issue Date: April 1, 2005.


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Analysis Shows Drug Could Save Lives From Prostate Cancer." ScienceDaily. ScienceDaily, 16 March 2005. <www.sciencedaily.com/releases/2005/03/050308093048.htm>.
John Wiley & Sons, Inc.. (2005, March 16). Analysis Shows Drug Could Save Lives From Prostate Cancer. ScienceDaily. Retrieved December 17, 2014 from www.sciencedaily.com/releases/2005/03/050308093048.htm
John Wiley & Sons, Inc.. "Analysis Shows Drug Could Save Lives From Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/03/050308093048.htm (accessed December 17, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, December 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins