Featured Research

from universities, journals, and other organizations

Three Anti-platelet Drugs Used In Combination Are Safe

Date:
March 15, 2005
Source:
Emory University Health Sciences Center
Summary:
Three drugs, each of which works in a different way, are used in anti-platelet therapy to help prevent restenosis (the reclogging of blood vessels after they have been cleared with percutaneous coronary intervention or PCI) or thrombosis (obstruction of an artery or vein by a blood clot).

ORLANDO -- Three drugs, each of which works in a different way, are used in anti-platelet therapy to help prevent restenosis (the reclogging of blood vessels after they have been cleared with percutaneous coronary intervention or PCI) or thrombosis (obstruction of an artery or vein by a blood clot). The use of these platelet inhibitory drugs -- cilostazol, clopidogrel and aspirin -- has resulted in a significant reduction of thrombotic complications in the primary and secondary prevention of heart attacks. But is it safe to use these medications together -- or in combination do they increase the risk of bleeding? And will patients comply with taking three pills?

Related Articles


In a poster session presented today at the American College of Cardiology's 54th Scientific Sessions in Orlando, Florida, Emory researchers say the answer to both questions is "yes".

The scientists analyzed data from the Cilostazol for RESTenosis (CREST) Trial, a randomized clinical trial testing the efficacy of cilostazol to prevent restenosis after PCI. Earlier results from CREST showed a 35% relative risk reduction in restenosis from 34% to 22% with cilostazol. The anti-thrombotic drugs Clopidogrel (75 mg daily for 30 days) and aspirin daily for 6 months were administered to all patients in the CREST trial while a total of 705 of these patients were randomized to cilostazol (354) or placebo (351) following successful angioplasty and stent implantation.

Twenty-nine patients experienced bleeding complications (17 major and 12 minor) but there was no significant difference in the rate of bleeding for patients who received aspirin plus clopidogrel plus cilostazol versus those who received aspirin plus clopidogrel. There was also no significant difference in type of bleeding (major or minor) experienced by these patients, no matter which drug therapy they were given.

"There was no evidence of increased risk of bleeding in patients treated with aspirin plus clopidogrel plus cilostazol and we also found that adherence to treatment was high," says Emory Heart Center cardiologist William Weintraub, MD, Director of the Emory Center for Outcomes Research, who participated in the study. "This is good news because all three anti-platelet medications work in somewhat different ways and in combination they may prove to have more efficacy."

In addition to Dr. Weintraub, the Emory research team included Jovonne K. Foster MS, Paul Kolm PhD, Grant T. Anderson, Karen M. Parker BS, John S. Douglas Jr. MD and Nancy VC Murrah RN,BSN. Drs. Douglas and Weintraub disclosed a commercial relationship with Otsuka American Pharmaceutical, Inc.


Story Source:

The above story is based on materials provided by Emory University Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

Emory University Health Sciences Center. "Three Anti-platelet Drugs Used In Combination Are Safe." ScienceDaily. ScienceDaily, 15 March 2005. <www.sciencedaily.com/releases/2005/03/050309144129.htm>.
Emory University Health Sciences Center. (2005, March 15). Three Anti-platelet Drugs Used In Combination Are Safe. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2005/03/050309144129.htm
Emory University Health Sciences Center. "Three Anti-platelet Drugs Used In Combination Are Safe." ScienceDaily. www.sciencedaily.com/releases/2005/03/050309144129.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins