Featured Research

from universities, journals, and other organizations

Study Says Rare Allergic Reactions To Drug-eluting Stents May Raise Risk For Heart Attack

Date:
March 17, 2005
Source:
Emory University Health Sciences Center
Summary:
Stents, tiny wire mesh tubes, are routinely used to prop arteries open after angioplasty clears them of potentially heart attack causing plaque. In the past, stented arteries often eventually closed up again with fatty deposits, a process called restenosis. However, since their FDA approval in 2003, stents coated with sirolimus (a pharmaceutical agent that prevents excess tissue growth) have been shown to greatly reduce restenosis. But some people suffer from rare, allergic-type reactions to the sirolimus-eluting stents (SES).

ORLANDO -- Stents, tiny wire mesh tubes, are routinely used to prop arteries open after angioplasty clears them of potentially heart attack causing plaque. In the past, stented arteries often eventually closed up again with fatty deposits, a process called restenosis. However, since their FDA approval in 2003, stents coated with sirolimus (a pharmaceutical agent that prevents excess tissue growth) have been shown to greatly reduce restenosis. But some people suffer from rare, allergic-type reactions to the sirolimus-eluting stents (SES).

According to research presented by Emory scientists at the American College of Cardiology's 54th annual Scientific Sessions in Orlando today, these hypersensitivity reactions to SES should be caught and treated early -- because those allergic to components of the drug-eluting stents appear to have a higher risk of cardiovascular complications, including heart attacks.

"Reports of stent thrombosis first raised suspicion of possible hypersensitivity allergic reactions. After more than 50 reports of hypersensitivity reactions to SES were received by the FDA through the medical device reporting system, the FDA issued a warning in the fall of 2003," says Emory Heart Center Interventional Cardiology Fellow Fadi Alameddine, MD. "We studied the frequency of hypersensitive reactions to SES to see whether they were linked to major adverse cardiovascular outcomes."

Dr. Alameddine, lead author of the research presented at a poster session today, notes that hypersensitivity to SES could be caused by the stent's metal, polymer, or sirolimus. In order to evaluate whether allergic reactions might result from components of the Cypher drug eluting stent made by Cordis, a team of Emory researchers examined data collected from a U.S. registry of patients implanted with the Cypher SES. Out of 2067 patients who received the Cypher stents between August and December of 2003, 39 patients (1.9%) had what appeared to be allergic reactions. Although non-Cypher stent causes were found in 28 patients with hypersensitivity reactions the remaining 11 patients had hypersensitivity symptoms (ranging from rash and hives to asthma) believed to be caused by SES.

"The group with the hypersensitivity reactions had a higher major adverse cardiovascular events (MACE) rate and there was a trend toward the need for target vessel revascularization (TVR). Most significantly, the 180 day myocardial infarction (MI) rate was statistically higher in the hypersensitivity group (7.9% vs. 1.1%)," says Dr. Alameddine.

The Emory researchers postulate that a hypersensitivity reaction may reflect a heightened inflammatory state, creating a predisposition for heart attack. "Another possible, but less likely, explanation for the increase in MI is that hypersensitivity might cause plaque in other coronary beds to become more vulnerable to rupture," says Dr. Alameddine.

Although the research needs to be confirmed by randomized controlled prospective trials, the observations indicate that careful monitoring for allergic reactions should follow deployment of drug-eluting stents, according to Dr. Alameddine. "The bottom line is that these reactions are very rare (about 1.8 percent). However, they can happen hours to weeks after stent deployment and physicians need to be aware of that possibility -- and when hypersensitivity does occur it needs to be treated in a timely manner and the increased risk of MI should be recognized," Dr. Alameddine states.

In addition to Dr. Alameddine, the research team included Aniket Kulkarn MD; Viola Vaccarino MD, PhD; and Peter C. Block, MD of Emory University Division of Cardiology, and Peter B. Berger, MD of Duke University Medical Center's Division of Cardiology. Dr. Berger disclosed commercial relationships with Bristol Myer Squibb/Sanofi, Cordis-Johnson & Johnson, Merck, Aventis, The Medicines Company, Genentech, and Guilford; Dr. Block, with Cordis-Johnson & Johnson.

###

The Emory Heart Center is comprised of all cardiac services and research at Emory University Hospital, the Carlyle Fraser Heart Center of Emory Crawford Long Hospital, the Andreas Gruentzig Cardiovascular Center of Emory University and The Emory Clinic. Ranked among the nation's top ten heart centers by U.S. News & World Report's annual survey, the Emory Heart Center has a rich history of excellence in all areas of cardiology and cardiac surgery --including education, research and patient care. It is internationally recognized as one of the birthplaces of modern interventional cardiology and was the site of the first coronary stent implantation in the United States, the only single site randomized comparison of angioplasty and bypass surgery, and pioneering work in vascular brachytherapy.


Story Source:

The above story is based on materials provided by Emory University Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

Emory University Health Sciences Center. "Study Says Rare Allergic Reactions To Drug-eluting Stents May Raise Risk For Heart Attack." ScienceDaily. ScienceDaily, 17 March 2005. <www.sciencedaily.com/releases/2005/03/050310110311.htm>.
Emory University Health Sciences Center. (2005, March 17). Study Says Rare Allergic Reactions To Drug-eluting Stents May Raise Risk For Heart Attack. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2005/03/050310110311.htm
Emory University Health Sciences Center. "Study Says Rare Allergic Reactions To Drug-eluting Stents May Raise Risk For Heart Attack." ScienceDaily. www.sciencedaily.com/releases/2005/03/050310110311.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins