Featured Research

from universities, journals, and other organizations

Sciatica Pain Study Seeks Volunteers

Date:
April 4, 2005
Source:
Washington University School Of Medicine
Summary:
Researchers at Washington University School of Medicine in St. Louis are testing the effectiveness of an investigational drug for the treatment of sciatica pain.

March 22, 2005 — Researchers at Washington University School of Medicine in St. Louis are testing the effectiveness of an investigational drug for the treatment of sciatica pain.

Sciatica involves pain in the lower back and hip that radiates down the thigh into the leg. It usually is caused by a combination of compressed nerve roots in the spinal cord and inflammation in the sciatic nerve. It often occurs with inflamed or herniated disks.

Pain from sciatica is called neuropathic pain because it is caused by damage to the nervous system. Many new therapies have been introduced to treat neuropathic pain, but not all patients benefit from existing therapies. This study is recruiting people with sciatica pain due to inflamed nerve roots in the lower back.

"Patients with sciatica often refer to their problem as a shooting pain like electricity down the leg," says anesthesiologist Rahul Rastogi, M.D., principal investigator, who sees patients at the Pain Management Center at Washington University and Barnes-Jewish Hospital. "Sometimes it also can be more of a burning pain or a tingling pain that resembles the feeling people get when their leg 'goes to sleep."

Rastogi and colleagues are studying the ability of the investigational drug REN-1654 to help control or eliminate that pain. The investigational medication is a novel, orally-active, small molecule inhibitor of TNF-alpha, a known proinflammatory cytokine which has been shown to be involved in neuropathology and pain associated with sciatica. REN-1654 is thought to have promise as a treatment for sciatica because it has been shown to interfere with communication between nerve cell receptors that may carry pain messages.

To be eligible for the study, volunteers must be between the ages of 18 and 55 and have leg pain radiating from the lower back to or below the knee that has been diagnosed as pain due to sciatica or to lumbar or lumbosacral radiculopathy. The onset of pain must have occurred two to 12 weeks prior to the initiation of study treatment.

Those who qualify for the study will receive a daily dose of either the study medication or an inactive placebo for three weeks. All participants will have their leg and back pain evaluated at one and three weeks after the start of treatment. Volunteers then will discontinue treatment and remain off medication for three weeks. At the end of those six weeks participants will be evaluated again.

Participation in the study is expected to last for about eight weeks Volunteers will receive free study-related physical exams, laboratory tests and investigational study medication. They will be compensated for time and travel.

The study will require five visits to the Pain Management Center, located in the Center for Advanced Medicine at Washington University and Barnes-Jewish Hospital.

For more information, call study coordinator Patty Suntrup at (314) 747-1709.


Story Source:

The above story is based on materials provided by Washington University School Of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Washington University School Of Medicine. "Sciatica Pain Study Seeks Volunteers." ScienceDaily. ScienceDaily, 4 April 2005. <www.sciencedaily.com/releases/2005/03/050326003200.htm>.
Washington University School Of Medicine. (2005, April 4). Sciatica Pain Study Seeks Volunteers. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2005/03/050326003200.htm
Washington University School Of Medicine. "Sciatica Pain Study Seeks Volunteers." ScienceDaily. www.sciencedaily.com/releases/2005/03/050326003200.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins