Featured Research

from universities, journals, and other organizations

Discovery Of A 'Molecular Switch' Could Lead To New Ways Of Treating Infection

Date:
April 27, 2005
Source:
Imperial College London
Summary:
The discovery of a 'molecular switch' could lead to new ways of treating infections such as MRSA, and inflammatory diseases like arthritis.

The discovery of a 'molecular switch' could lead to new ways of treating infections such as MRSA, and inflammatory diseases like arthritis.

According to research published today in Nature, the team from Imperial College London and the University of California, San Diego, have identified an enzyme called IKKa, which can act as a 'brake' on an immune cell pathway responsible for regulating the body's response to infection and inflammation.

By inhibiting IKKa activity the researchers were able to increase the body's ability to fight off infection, but at the same time also increased the body's inflammatory response. They also found that IKKa inhibits activation of immune cells, and inhibits inflammation, a discovery which could lead to new ways of treating diseases such as arthritis.

Dr Toby Lawrence, a Wellcome Trust International Research Fellow from Imperial College London, based at the Kennedy Institute of Rheumatology, and lead author of the research, says: "The identification of this 'double-edged sword' could be of huge importance in how we deal with a number of major health issues, including MRSA. With antibacterial resistance on the rise, this development could provide doctors with a new way to stop infections without resorting to a cocktail of antibiotics.

"Although this is only a first step, the discovery could also help arthritis sufferers. By increasing IKKa activity we may be able to stop inflammation, and possibly develop a new treatment."

The team investigated the role of IKKa in inflammation and immunity by comparing the response of mice with a defective IKKa enzyme, compared to normal mice, when exposed to the pathogen Streptococcus. In the mice without IKKa, they found significantly increased killing of bacteria in sepsis and pneumonia, but found that inflammation was higher than the normal mice. This result led the team to believe that IKKa was a stop signal to limit the inflammatory response.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Discovery Of A 'Molecular Switch' Could Lead To New Ways Of Treating Infection." ScienceDaily. ScienceDaily, 27 April 2005. <www.sciencedaily.com/releases/2005/04/050427134835.htm>.
Imperial College London. (2005, April 27). Discovery Of A 'Molecular Switch' Could Lead To New Ways Of Treating Infection. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2005/04/050427134835.htm
Imperial College London. "Discovery Of A 'Molecular Switch' Could Lead To New Ways Of Treating Infection." ScienceDaily. www.sciencedaily.com/releases/2005/04/050427134835.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins