Featured Research

from universities, journals, and other organizations

Prenatal Cocaine Exposure Increases Heart Susceptibility To Ischemia, Reperfusion Injury In Adult Male But Not Female Rats

Date:
May 13, 2005
Source:
Blackwell Publishing Ltd.
Summary:
Cocaine abuse is becoming increasingly prevalent among women of childbearing age, and is associated with numerous adverse perinatal outcomes. New research, published in The Journal of Physiology, by Professor Lubo Zhang and his research team from Loma Linda University School of Medicine in California presents the exciting novel finding that cocaine exposure in utero has lasting and lifelong adverse effects on the heart in adulthood, particularly if you are male!

Cocaine abuse is becoming increasingly prevalent among women of childbearing age, and is associated with numerous adverse perinatal outcomes. New research, published in The Journal of Physiology, by Professor Lubo Zhang and his research team from Loma Linda University School of Medicine in California presents the exciting novel finding that cocaine exposure in utero has lasting and lifelong adverse effects on the heart in adulthood, particularly if you are male!

Professor Zhang's research group has been studying the effect of adverse intrauterine environment on fetal heart development and its lifelong pathophysiological consequences in the adult heart. Using an animal model of the pregnant rat, they found that fetal exposure to cocaine during gestation resulted in an increase in heart susceptibility to ischaemia and reperfusion injury in late adult life. Interestingly, the effect of prenatal cocaine exposure on cardiac vulnerability in adult offspring is gender-dependent, with the male heart being more susceptible to increased ischaemia/reperfusion injury induced by prenatal cocaine exposure.

Earlier work by professor Zhang's group showed that fetal chronic hypoxia also increased cardiac vulnerability to ischaemia and reperfusion injury in late adult life.

Epidemiological studies in humans have shown an association of fetal undernutrition in the womb and an increased risk of hypertension and ischaemic heart disease in adulthood. In addition to undernutrition as originally proposed, professor Zhang's studies suggest that other adverse factors such as cocaine abuse and hypoxia during gestation also cause fetal programming in utero, which has lasting and lifelong effects on the cardiovascular system in later adult life.

Acute ischaemic injury and myocardial infarction resulting from coronary artery disease is the major cause of death among people in the western world. Despite years of research, the causes for ischaemic heart disease are incompletely understood. The new studies from Professor Zhang's research group at Loma Linda University provide clear evidence in an animal model for the first time that ischaemic heart disease in adulthood can originate through fetal programming under an adverse intrauterine environment.

The findings are important because they provide novel insights that improve our understanding of risk factors for cardiovascular diseases including ischaemic heart disease, and link prenatal cocaine exposure and fetal hypoxia to their lifelong pathophysiological consequences in the adult heart. Because cocaine abuse and hypoxia are common problems in fetal development, these findings have obvious clinical significance.

The next step is to investigate the epigenetic mechanisms involved in fetal programming caused by adverse intrauterine environment, which is essential for explaining many fundamental biological processes by which a variety of cardiovascular dysfunctions and diseases emerge and evolve.



Story Source:

The above story is based on materials provided by Blackwell Publishing Ltd.. Note: Materials may be edited for content and length.


Cite This Page:

Blackwell Publishing Ltd.. "Prenatal Cocaine Exposure Increases Heart Susceptibility To Ischemia, Reperfusion Injury In Adult Male But Not Female Rats." ScienceDaily. ScienceDaily, 13 May 2005. <www.sciencedaily.com/releases/2005/05/050512111941.htm>.
Blackwell Publishing Ltd.. (2005, May 13). Prenatal Cocaine Exposure Increases Heart Susceptibility To Ischemia, Reperfusion Injury In Adult Male But Not Female Rats. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2005/05/050512111941.htm
Blackwell Publishing Ltd.. "Prenatal Cocaine Exposure Increases Heart Susceptibility To Ischemia, Reperfusion Injury In Adult Male But Not Female Rats." ScienceDaily. www.sciencedaily.com/releases/2005/05/050512111941.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins