Featured Research

from universities, journals, and other organizations

Research Offers Hope Of New Treatments For Liver Damage

Date:
May 31, 2005
Source:
British Information Services
Summary:
The Edinburgh scientists from the University's Centre for Inflammation Research, in collaboration with colleagues from the University of Southampton and Cincinnati, Ohio have, for the first time, identified two separate populations of immune cells --macrophages--in the liver. One group of macrophages causes scarring to the liver, but the next wave of immune cells, produced only a few days later, change function to break down and reabsorb the scarring.

There is currently no cure for liver cirrhosis and a patient's only hope of survival is to receive a liver transplant.

Related Articles


The Edinburgh scientists from the University's Centre for Inflammation Research, in collaboration with colleagues from the University of Southampton and Cincinnati, Ohio have, for the first time, identified two separate populations of immune cells --macrophages--in the liver. One group of macrophages causes scarring to the liver, but the next wave of immune cells, produced only a few days later, change function to break down and reabsorb the scarring. These findings, published in the January edition of Journal of Clinical Investigation, will help doctors to understand the mechanisms by which the liver is damaged and repaired and may lead to future treatments.

Researcher Dr Jeremy Duffield explained: "The links between the immune system, inflammation and scarring in the liver have not been well understood, and this has hindered progress in finding ways to prevent and repair liver damage. Now that we have shown how the macrophages work, we aim to find out how to create, activate and de-activate these cells to make them repair, rather than damage, liver tissue."

He added: "Cirrhosis, commonly, but not always, caused by alcohol consumption, can lead to liver failure. At a time when outcomes for other diseases, such as cancers and heart trouble, have made dramatic gains, liver damage --described as the new plague of the 21st century --has yet to be understood and in turn, to become treatable. More women in the UK now die of liver failure than do of cancer of the cervix.

"There has been a fourfold increase in the number of men aged 45-54 dying of cirrhosis since 1970 and a threefold increase in women of the same age group. Liver failure is also rapidly increasing in younger people with the deaths in the UK of 500 men and 300 women aged 25-44, in 2003."

Professor John Iredale of the University of Southampton said: "We are facing a huge increase in the numbers of patients with advanced liver fibrosis (scarring) and cirrhosis (end stage scarring of the liver). Currently, we have no effective treatment for liver cirrhosis which is associated with internal bleeding, liver failure and the development of primary liver cancer. There is a huge imperative to develop new approaches to the treatment of liver scarring. Exciting insights such as these will inform the design of future therapies."

Further research into macrophages is set to follow and scientists will explore the role of these immune-system cells in damage and repair to other organs, including the kidney.


Story Source:

The above story is based on materials provided by British Information Services. Note: Materials may be edited for content and length.


Cite This Page:

British Information Services. "Research Offers Hope Of New Treatments For Liver Damage." ScienceDaily. ScienceDaily, 31 May 2005. <www.sciencedaily.com/releases/2005/05/050528142800.htm>.
British Information Services. (2005, May 31). Research Offers Hope Of New Treatments For Liver Damage. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2005/05/050528142800.htm
British Information Services. "Research Offers Hope Of New Treatments For Liver Damage." ScienceDaily. www.sciencedaily.com/releases/2005/05/050528142800.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins