Featured Research

from universities, journals, and other organizations

Researchers Improve Lung Cancer Survival Rates

Date:
June 24, 2005
Source:
University of Alberta
Summary:
A Canadian national clinical trial has found that chemotherapy following surgery for early-stage non-small cell lung cancer significantly improves survival for the disease over just surgery alone.

A Canadian national clinical trial has found that chemotherapy following surgery for early-stage non-small cell lung cancer significantly improves survival for the disease over just surgery alone.

The research, funded by the Canadian Cancer Society and appearing in tomorrow's issue of the New England Journal of Medicine, is already making an impact around the world.

"With the very significant benefits documented in this study, we are recommending that a brief course of chemotherapy after surgery should be the new standard of care around the world," says Canadian Cancer Society researcher Dr. Timothy Winton, chair of the study and associate professor and director of the Division of Thoracic Surgery at the University of Alberta Hospital in Edmonton.

"In fact, when post-operative chemotherapy was adopted as a standard of care in breast and colon cancer, it was based on data demonstrating much less benefit to what we have now achieved for lung cancer patients," he added.

In the seven-year study involving 482 patients from Canada and the United States, investigators led by Dr. Winton found that post-surgical treatment with the chemotherapy drugs vinorelbine and cisplatin increased the survival rate after five years by 15 per cent. Prior to this research, surgery was the only treatment available for patients with this common type of lung cancer, but the tumour often recurred outside of the lung within a few years and was then incurable.

"Cancer care specialists throughout Canada, the United States, United Kingdom, Scandinavia, Europe, South East Asia and Australia are now giving chemotherapy treatment after surgery to their patients with early-stage non-small cell lung cancer," says Dr. Frances Shepherd, chair of the lung site group committee of the National Cancer Institute of Canada Clinical Trials Group, the organization that coordinated the study. Dr. Shepherd is also a medical oncologist at Princess Margaret Hospital in Toronto and professor of medicine at the University of Toronto.

Lung cancer is one of the most common forms of cancer worldwide, and is the leading cause of death from cancer in North America. Non-small cell lung cancer is the most common type of lung cancer, accounting for more than 80 per cent of all cases. An estimated 22,200 Canadians will be diagnosed with lung cancer this year.

In the study, 242 patients with stage Ib or II non-small cell lung cancer whose tumours had been completely removed received a 16-week course of vinorelbine and cisplatin shortly after surgery. Their outcomes were compared to 240 patients who received surgery alone. In addition to a 15 per cent improvement in the five-year survival rate (69 per cent with chemotherapy versus 54 per cent in the surgery alone group), the rate of cancer recurrence after five years was also significantly reduced--49 per cent in chemotherapy patients versus 61 per cent with patients who received surgery alone.

Among those who did have their cancer relapse, the time between surgery and recurrence was also significantly longer among chemotherapy patients compared to the surgery alone patients.

"These major benefits were achieved with an inexpensive, short period of treatment with limited, short-lived toxic side effects and no major long-term impacts on quality of life," adds Dr. Winton.

Dr. Barbara Whylie, CEO of the Canadian Cancer Society, says "Canadian researchers are breaking through the barriers of what can be achieved in the treatment of lung cancer. Their leadership in this important area will have a significant impact on the lives of people with lung cancer in Canada and around the world. We're delighted to have been a key player in supporting this work."

The lung cancer clinical trial was coordinated by the National Cancer Institute of Canada Clinical Trials Group, which is funded by the Canadian Cancer Society. The Clinical Trials Group is based at Queen's University in Kingston, Ont. With Society funding, the Clinical Trials Group has participated in many groundbreaking trials that have helped change treatment or improve the quality of life for cancer patients worldwide. This research was also supported by the National Cancer Institute in the United States, GlaxoSmithKline and the Canadian Institutes of Health Research.

###

The Canadian Cancer Society is a national community-based organization of volunteers whose mission is to eradicate cancer and to enhance the quality of life of people living with cancer. When you want to know more about cancer, visit our website at www.cancer.ca or call our toll-free, bilingual Cancer Information Service at 1 888 939-3333.


Story Source:

The above story is based on materials provided by University of Alberta. Note: Materials may be edited for content and length.


Cite This Page:

University of Alberta. "Researchers Improve Lung Cancer Survival Rates." ScienceDaily. ScienceDaily, 24 June 2005. <www.sciencedaily.com/releases/2005/06/050622232959.htm>.
University of Alberta. (2005, June 24). Researchers Improve Lung Cancer Survival Rates. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2005/06/050622232959.htm
University of Alberta. "Researchers Improve Lung Cancer Survival Rates." ScienceDaily. www.sciencedaily.com/releases/2005/06/050622232959.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins