Featured Research

from universities, journals, and other organizations

UCI Researchers Define Estrogen's Role In Limiting Heart Disease In Women

Date:
July 20, 2005
Source:
University of California - Irvine
Summary:
UC Irvine School of Medicine researchers have identified how estrogen helps prevent a cardiac ailment often seen in women who have heart attacks. This research provides further evidence that hormone replacement therapy after menopause can help prevent certain forms of cardiovascular disease in women.

UC Irvine School of Medicine researchers have identified how estrogen helps prevent a cardiac ailment often seen in women who have heart attacks. This research provides further evidence that hormone replacement therapy after menopause can help prevent certain forms of cardiovascular disease in women.

In tests done on female mice and mice heart cells, Dr. Ellis R. Levin and his UCI colleagues found that estrogen triggers molecular activity that blocks cardiac hypertrophy, or heart enlargement. This thickening of tissue in the heart ventricles is seen in almost 80 percent of people following heart attacks. Cardiac hypertrophy also commonly results from long-standing hypertension and leads to a poorly functioning heart and heart failure in many instances. Previous studies have indicated that premenopausal women have lower rates of heart disease than men, a rate that significantly rises in women after menopause.

Study results appear in the July 15 issue of the Journal of Biological Chemistry.

The results will continue a debate raised by the Women’s Health Initiative over whether estrogen plays any beneficial role with cardiac disease in women. The initiative is a recently completed 15-year research program funded by the National Institutes of Health to address the most common causes of death, disability and poor quality of life in postmenopausal women, and some of its study data indicated that estrogen offered no protection against the development of arteriosclerotic heart disease. A recent article published in Science by Drs. Michael Mendelsohn and Richard Karas of Tufts University School of Medicine, however, addressed concerns of drawing conclusions based on the Women’s Health Initiative data.

“There has been intense reaction to the Women’s Health Initiative report indicating that estrogen is not beneficial in preventing coronary heart disease,” said Levin, a professor of medicine, biochemistry and pharmacology, and director of endocrinology at UCI and the affiliated Veterans Affairs Medical Center in Long Beach, Calif. “Our work suggests that further in-depth studies should be undertaken to determine if estrogen supplements prevent cardiac hypertrophy, especially in postmenopausal women with risk factors for this disorder. Existing research results in women support this concept.”

Estrogen is needed for normal growth and development of female sex organs and for functions such as bearing children. But during menopause, the body’s production of estrogen decreases. Estrogen replacement is used for symptoms associated with menopause and for the prevention of osteoporosis in postmenopausal women. Estrogen supplements, though, have been linked to higher rates of breast cancer.

This study follows another published in the Journal of Biological Chemistry earlier this year, in which the laboratories of Levin and Ghassan Kassab, professor of biomedical engineering at UCI, showed that estrogen causes dilation of the arteries in female mice. Such an effect could compensate for the damaging effects of hypertension on blood vessels.

Mahnaz Razandi, Ali Pedram and Mark Aitkenhead of UCI assisted with the study. The Department of Veterans Affairs and the National Institutes of Health provided support.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Irvine. "UCI Researchers Define Estrogen's Role In Limiting Heart Disease In Women." ScienceDaily. ScienceDaily, 20 July 2005. <www.sciencedaily.com/releases/2005/07/050720063531.htm>.
University of California - Irvine. (2005, July 20). UCI Researchers Define Estrogen's Role In Limiting Heart Disease In Women. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2005/07/050720063531.htm
University of California - Irvine. "UCI Researchers Define Estrogen's Role In Limiting Heart Disease In Women." ScienceDaily. www.sciencedaily.com/releases/2005/07/050720063531.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins