Featured Research

from universities, journals, and other organizations

High Insulin Levels Increase Inflammatory Markers And Beta-amyloids, May Contribute To Alzheimer's

Date:
August 12, 2005
Source:
JAMA and Archives Journals
Summary:
Moderately elevated levels of insulin increase the levels of inflammatory markers and beta-amyloid in plasma and in cerebrospinal fluid, and these markers may contribute to Alzheimer's disease, according to a new study posted online today from Archives of Neurology, one of the JAMA/Archives journals. The study will be published in the October print edition of the journal.

CHICAGO -- Moderately elevated levels of insulin increase the levels ofinflammatory markers and beta-amyloid in plasma and in cerebrospinalfluid, and these markers may contribute to Alzheimer's disease,according to a new study posted online today from Archives ofNeurology, one of the JAMA/Archives journals. The study will bepublished in the October print edition of the journal.

According to background information in the article, "conditions ofinsulin resistance and hyperinsulinemia are associated with elevatedlevels of inflammatory markers and increase the risk for Alzheimerdisease (AD). Inflammation has been proposed as a key pathogenic factorfor AD."

Mark A. Fishel, M.D., from the University of Washington,Seattle, and colleagues, raised blood insulin levels (while maintainingnormal blood sugar levels) in 16 healthy older adults ranging in agefrom 55 to 81 years, and then measured the changes in levels ofinflammatory markers, modulators, and beta-amyloid (a proteinassociated with AD) in plasma and cerebrospinal fluid.

"Moderate peripheral hyperinsulinemia (increased levels ofinsulin) provoked striking increases in CNS (central nervous system)inflammatory markers," the authors report. "Our findings suggest thatinsulin-resistant conditions such as diabetes mellitus and hypertensionmay increase the risk for AD, in part through insulin-inducedinflammation."

"Although this model has obvious relevance for diabetesmellitus, hyperinsulinemia and insulin resistance are widespreadconditions that affect many nondiabetic adults with obesity, impairedglucose tolerance, cardiovascular disease, and hypertension. Ourresults provide a cautionary note for the current epidemic of suchconditions, which, in the context of an aging population, may provoke adramatic increase in the prevalence of AD. More encouragingly, greaterunderstanding of insulin's role in AD pathogenesis may lead to noveland more effective strategies for treating, delaying, or evenpreventing this challenging disease," the authors conclude.

###

(Arch Neurol. 2005; 62: 1-6. Available pre-embargo for the media at www.jamamedia.org)Editor's Note: This work was supported by the Department of VeteransAffairs, Washington, D.C., by grants from the National Institute onAging, Bethesda, Md., and by the Alvord Endowment, University ofWashington, Seattle.



Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "High Insulin Levels Increase Inflammatory Markers And Beta-amyloids, May Contribute To Alzheimer's." ScienceDaily. ScienceDaily, 12 August 2005. <www.sciencedaily.com/releases/2005/08/050811105347.htm>.
JAMA and Archives Journals. (2005, August 12). High Insulin Levels Increase Inflammatory Markers And Beta-amyloids, May Contribute To Alzheimer's. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2005/08/050811105347.htm
JAMA and Archives Journals. "High Insulin Levels Increase Inflammatory Markers And Beta-amyloids, May Contribute To Alzheimer's." ScienceDaily. www.sciencedaily.com/releases/2005/08/050811105347.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins