Featured Research

from universities, journals, and other organizations

Breast Cancer Gene Increases Risk Of Several Cancers In Men

Date:
September 6, 2005
Source:
BMJ Specialty Journals
Summary:
A genetic mutation implicated in an increased risk of breast and ovarian cancers also significantly increases the risk of pancreatic and prostate cancers in men, finds research in the Journal of Medical Genetics. The mutation in the BRAC2 gene may also increase the risk of bone and throat cancers, the data suggest.

A genetic mutation implicated in an increased risk of breast andovarian cancers also significantly increases the risk of pancreatic andprostate cancers in men, finds research in the Journal of Medical Genetics.

The mutation in the BRAC2 gene may also increase the risk of bone and throat cancers, the data suggest.

The Dutch researchers investigated 139 families with 66different mutations of the BRAC2 gene between them. The families wereall drawn from a national register of families with breast and ovariancancers in several family members.

To provide a more accurate picture of risk, the researchersavoided the known carriers, and studied the incidence of cancers amongfamily members with a 50% chance of being a carrier, amounting to 1811people.

They then calculated the overall risk of developing thesecancers in comparison with the expected rates in the generalpopulation.

Among the 441 people who were tested for BRAC2, just over two thirds (69%) carried the mutation.

In total, there were 158 cases of cancer among the 303 carriersof the genetic mutation compared with just 18 cases among the 138 whodid not carry the mutation.

There were higher numbers of prostate, pancreatic, pharyngeal and bone cancers than would be expected in the general population.

Compared with the general population carriers of the BRAC2genetic mutation were almost seven times and eight times as likely tohave, respectively, pharyngeal and pancreatic cancers. Male carrierswere more than twice as likely to have prostate cancer.

Carriers were also around 15 times as likely to have bonecancer, although the authors point out that this could have been theresult of spread from another primary cancer.

Almost all of these increased risks were significant for men only, and tended to be stronger for people under the age of 65.

As 11 of the 24 men with prostate cancer had died, the authorssuggest that early radical treatment for the disease might be offeredto men who carry the genetic mutation, rather than the watchfulwaiting, which is common policy.

###

[Cancer risks in BRCA2 families: estimates for sites other than breast and ovary J Med Genet 2005; 42: 711-19]



Story Source:

The above story is based on materials provided by BMJ Specialty Journals. Note: Materials may be edited for content and length.


Cite This Page:

BMJ Specialty Journals. "Breast Cancer Gene Increases Risk Of Several Cancers In Men." ScienceDaily. ScienceDaily, 6 September 2005. <www.sciencedaily.com/releases/2005/09/050906075038.htm>.
BMJ Specialty Journals. (2005, September 6). Breast Cancer Gene Increases Risk Of Several Cancers In Men. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2005/09/050906075038.htm
BMJ Specialty Journals. "Breast Cancer Gene Increases Risk Of Several Cancers In Men." ScienceDaily. www.sciencedaily.com/releases/2005/09/050906075038.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com
Lost Brain Cells To Blame For Sleep Problems Among Seniors

Lost Brain Cells To Blame For Sleep Problems Among Seniors

Newsy (Aug. 21, 2014) According to a new study, elderly people might have trouble sleeping because of the loss of a certain group of neurons in the brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins