Featured Research

from universities, journals, and other organizations

New Study Suggests Mechanism Of Action For Botox In The Treatment Of Enlarged Prostate

Date:
September 6, 2005
Source:
University of Pittsburgh Medical Center
Summary:
Botox® appears to alter specific cellular processes that contribute to prostate enlargement according to new study results presented by researchers from the University of Pittsburgh and Chang Gung Memorial Hospital in Taiwan at the International Continence Society annual meeting in Montreal.

Botox® appears to alter specific cellular processes that contribute to prostate enlargement according to new study results presented by researchers from the University of Pittsburgh and Chang Gung Memorial Hospital in Taiwan at the International Continence Society annual meeting in Montreal.

"Most men consider an enlarged prostate and the irritating symptoms that accompany it as an inevitability of aging and may not seek help because currently available therapies can have serious side effects, including impotence," said Michael Chancellor, M.D., professor of urology at the University of Pittsburgh School of Medicine. "Alternative treatments are needed and we've taken an important step by demonstrating how Botox can work as a potential new therapy for the large number of men who suffer from this condition."

The research team had previously demonstrated that injection of Botox (botulinum toxin A) into the prostate gland produced improvement in symptoms such as the frequent urge to urinate, incomplete emptying of the bladder and low urine flow rate in men with bladder outlet obstruction due to BPH. The current study was conducted to investigate the mechanism of action by which Botox might work to reduce these symptoms.

For this study, researchers injected varying doses of Botox into the enlarged prostates of adult male rats. One week after injection, two types of altered cellular dynamics were observed, including an increase in apoptosis (cell death) and inhibition of cell proliferation, and down-regulation of adrenergic receptors in the prostate. Adrenergic receptors cause the contraction of the prostate and bladder muscles, making it difficult to void urine. By blocking these receptors, the muscles relax, allowing urine to flow more freely.

BPH is a non-cancerous growth of the prostate that can interfere with urination. It is one of the most common diseases affecting men, with current studies indicating that more than half of all men over the age of 60, and 80 percent of all men by age 80, will have enlarged prostates. Forty to 50 percent of the men who develop enlarged prostates will present with symptoms which include more frequent urination, urinary tract infections, the inability to completely empty the bladder, and, in severe cases, damage to the bladder and kidneys.

The study results were presented at the meeting as non-discussion poster # 237.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "New Study Suggests Mechanism Of Action For Botox In The Treatment Of Enlarged Prostate." ScienceDaily. ScienceDaily, 6 September 2005. <www.sciencedaily.com/releases/2005/09/050906080940.htm>.
University of Pittsburgh Medical Center. (2005, September 6). New Study Suggests Mechanism Of Action For Botox In The Treatment Of Enlarged Prostate. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2005/09/050906080940.htm
University of Pittsburgh Medical Center. "New Study Suggests Mechanism Of Action For Botox In The Treatment Of Enlarged Prostate." ScienceDaily. www.sciencedaily.com/releases/2005/09/050906080940.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) — Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins