Featured Research

from universities, journals, and other organizations

Prevent Prostate Cancer With Antioxidants? Gene Pathway May Reveal More Clues

Date:
September 16, 2005
Source:
Johns Hopkins Medical Institutions
Summary:
Scientists from Maryland and New Jersey have identified a molecular pathway in mice that makes prostate cells vulnerable to cancer-causing oxygen damage. The pathway, which is also involved in human prostate cancer, may help determine how and whether antioxidants, such as certain vitamins or their products that reverse the damage, can prevent prostate cancer.

Scientists from Maryland and New Jersey have identified a molecularpathway in mice that makes prostate cells vulnerable to cancer-causingoxygen damage. The pathway, which is also involved in human prostatecancer, may help determine how and whether antioxidants, such ascertain vitamins or their products that reverse the damage, can preventprostate cancer.

Related Articles


The researchers, from Johns Hopkins Kimmel Cancer Center and TheCancer Institute of New Jersey, found that when the tumor suppressorgene Nkx3.1 malfunctions, prostate cells lose the ability to protectthemselves from oxygen damage. Results of the new studies are in theAugust issue of the journal Cancer Research.

"Normally, cells with functioning Nkx3.1 seem to processoxidative free radicals appropriately," says Theodore L. DeWeese, M.D.,a co-author of the study and director of the Department of RadiationOncology & Molecular Radiation Sciences at Hopkins. "But cells withfaulty Nkx3.1 genes cannot manage oxidative injury. Then, their DNAgets damaged, and that leads to other mutations that in turn can bringabout cancer."

The researchers specifically found that a key role ofNkx3.1 is to prevent oxidative damage by regulating the expression ofother genes. Oxygen causes cellular degeneration through so-calledoxidative free radicals --- highly reactive atoms with an unpairedelectron that can rip through cells like a bullet. Free radicals areproduced as a result of normal body metabolism, and are widely known tobe intimately involved in aging, as well as cancer development.

"Our findings provide new insights regarding therelationship between loss of protection against oxidative stress andthe initiation of prostate cancer," adds Cory Abate-Shen, Ph.D., seniorstudy author and professor of medicine and neuroscience, member at theCenter for Biotechnology and Medicine at UMDNJ-Robert Wood JohnsonMedical School. "One key finding is that defects in the oxidativeresponse pathway occur early in prostate cancer development."Abate-Shen also is co-director of the Prostate Cancer Program at theCancer Institute of New Jersey.

For the study, the researchers used a sophisticated computertechnique called gene expression profiling to compare in-depth thegenetic makeup of mice whose Nkx3.1 gene was disrupted with that ofnormal mice. The method takes all DNA from the cells and allowsscientists to look for aberrations. DeWeese likens it to studyingthousands of pages of an encyclopedia simultaneously; trying toidentify what pages may have been altered.

They observed that mice with malfunctioning Nkx3.1 incorrectlyexpressed 638 genes, including those that created a significantreduction in some antioxidant enzymes vital to oxidative damageprevention. These alterations occurred in mice as early as four monthsof age - well before cellular changes are visible in the mouseprostate. The mutant mice also displayed a fivefold increase in theamount of cancer-related DNA damage, called8-hydroxy-2'-deoxyguanosine.

Further investigation showed that the progression toprostate cancer as it occurs in mice lacking Nkx3.1 and another tumorsuppressor, Pten, correlated with additional deregulation ofantioxidants and more profound accumulations of oxidative damage to DNAand protein.

"Mice with defective Nkx3.1 provide a valuable tool forpreclinical studies to test whether antioxidants might be useful forprostate cancer prevention," Abate-Shen says and continuing studieswill test antioxidants or other agents on the altered mice.

Prostate cancer is the most commonly diagnosed cancer in menand ranks second to lung cancer as the leading cause of cancer deathamong American men. More than 232,000 cases of prostate cancer arediagnosed and treated annually in the United States, and close to30,000 men die each year of the disease. Most men over the age of 50will have some experience with prostate disease -- with either anenlarged prostate or cancer.

###

The study was supportedby the National Institutes of Health. Co-authors were Xuesong Ouyang ofUMDNJ-Robert Wood Johnson Medical School, and William G. Nelson ofHopkins.

Liks:
Johns Hopkins Kimmel Cancer Centerhttp://www.hopkinskimmelcancercenter.org
The Cancer Institute of New Jerseyhttp://www.cinj.org/
Jhu_science_and_medicine_news mailing list[email protected]
http://resource2.ca.jhu.edu/mailman/listinfo/jhu_science_and_medicine_news


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Prevent Prostate Cancer With Antioxidants? Gene Pathway May Reveal More Clues." ScienceDaily. ScienceDaily, 16 September 2005. <www.sciencedaily.com/releases/2005/09/050916074339.htm>.
Johns Hopkins Medical Institutions. (2005, September 16). Prevent Prostate Cancer With Antioxidants? Gene Pathway May Reveal More Clues. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2005/09/050916074339.htm
Johns Hopkins Medical Institutions. "Prevent Prostate Cancer With Antioxidants? Gene Pathway May Reveal More Clues." ScienceDaily. www.sciencedaily.com/releases/2005/09/050916074339.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins