Featured Research

from universities, journals, and other organizations

Microtubules Critical To Development Of Mental Disorders

Date:
September 18, 2005
Source:
University at Buffalo
Summary:
Neuroscientists at the University at Buffalo have shown in two recently published papers that destabilization of structures called microtubules, intracellular highways that transport receptors to their working sites in the brain, likely underlie many mental disorders and could be promising targets for intervention.

Related Articles


Intheir most recent article, published in the Aug. 19 issue of theJournal of Biological Chemistry, they report that destabilization ofmicrotubules interferes with the action of the NMDA receptor, a targetof the neurotransmitter glutamate, which plays a critical role inlearning and memory.

"You can think of NMDAR as the cargo movingalong a railway consisting of the microtubules cytoskeleton," said leadauthor Eunice Yuen, graduate student in the laboratory of Zhen Yan,Ph.D., associate professor in the Department of Physiology andBiophysics, UB School of Medicine and Biomedical Sciences.

"Microtubulesare hollow cylinders made up of polymers of the protein tubulin," shesaid. "Agents that break up, or depolymerize, microtubules disrupt therailway, stop the traffic and reduce the number of cargoes that getdelivered to the neuronal surface.

"In turn, fewer NMDA receptorsare available on the surface of the neuron to interact with itsneurotransmitter, which results in fewer signals being transmitted tocritical areas of the brain," said Yuen. "Defects in neuronal transportare involved in many neurological diseases."

In an earlier paperfrom Yan's group published in the June 8 issue of the Journal ofNeuroscience, the researchers showed that the neuromodulator serotonin,crucial to the treatment of depression and anxiety, also regulates NMDAreceptor function through the mechanism dependent on microtubules. Yanwas senior author on both papers.

"We hypothesize that thefunction of the serotonin receptor known as 5-HT1AR is to suppress theactivity of the NMDA receptor by coupling to cellular signaling, whichdepolymerizes microtubules,"

said Yuen, first author on thepaper. "The breakup of microtubules, in turn, interrupts NMDAR deliveryto the neuronal surface, resulting in suppression of NMDAR function.

"Thisevidence shows that serotonin can regulate NMDAR transport along themicrotubule cytoskeleton in neurons," she said. "Dysfunction of thisregulation may provide a potential mechanism underlying many mentaldisorders."

Also contributing to these studies were Zhenglin Gu,post-doctoral associate, and Paul Chen, medical and doctoral student inYan's laboratory, and Qian Jiang, post-doctoral associate in thelaboratory of Jian Feng, Ph.D., UB associate professor of physiologyand biophysics.

The studies were supported by grants from theNational Institutes of Health and the National Science Foundation, anda National Alliance for Research on Schizophrenia and DepressionIndependent Investigator Award to Yan.

The University at Buffalois a premier research-intensive public university, the largest and mostcomprehensive campus in the State University of New York.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University at Buffalo. "Microtubules Critical To Development Of Mental Disorders." ScienceDaily. ScienceDaily, 18 September 2005. <www.sciencedaily.com/releases/2005/09/050918132521.htm>.
University at Buffalo. (2005, September 18). Microtubules Critical To Development Of Mental Disorders. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2005/09/050918132521.htm
University at Buffalo. "Microtubules Critical To Development Of Mental Disorders." ScienceDaily. www.sciencedaily.com/releases/2005/09/050918132521.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins