Featured Research

from universities, journals, and other organizations

Columbia Scientists Develop Cancer Terminator Viruses

Date:
September 20, 2005
Source:
Columbia University Medical Center
Summary:
Columbia scientists believe that the "terminator" viruses have the potential to become effective treatments for a wide range of tumors - such as ovarian, pancreatic, breast, brain (glioma), prostate, skin (melanoma) and colon cancer - because the virus is constructed to exploit a characteristic of all solid cancers.

Bothpapers were led by Paul B. Fisher, M.Ph., Ph.D., professor of clinicalpathology and the Michael and Stella Chernow Urological Cancer ResearchScientist at Columbia University College of Physicians and Surgeons.

Inthe Cancer Research paper, the researchers discuss the development of a"terminator" virus, which was administered to mice with pancreaticcancers at both primary and distant sites (akin to metastases). Aspredicted, when the virus was injected directly into the primary tumor,the virus destroyed not only the primary tumor, but also distanttumors. While the infection caused by the virus was sufficient to killthe primary tumor, a second weapon added to the virus ‘Vinterferon-gamma (IFN-ƒΧ) ‘V eliminated the metastases. IFN-ƒΧ elicitedan anti-tumor immune response against the distant metastatic cancercells.

In the PNAS paper, Dr. Fisher and the team describe theproduction of a virus conceptually similar to the "terminator" virus,which selectively replicates and kills breast cancer cells in mice.Human breast tumor xenografts were established on both sides ofimmune-deficient mice. Results found that treating the tumors on justone side of the animal with very few injections of this modified virusnot only cured the injected tumors, but also resulted in thedestruction of the tumors on the opposite side of the animal. Insteadof carrying IFN-ƒΧ as the other virus did, this virus carried a genecalled mda-7/IL-24, a novel gene identified and cloned in Dr. Fisher'slaboratory, which is selectively toxic to cancer cells and is now inphase II clinical trials as a cancer gene therapeutic.

"We areextremely excited about these results and the prospect of one day usinga form of the cancer terminator virus in human clinical trials," saidDr. Fisher, the study's senior author. "While the results of thesetrials need to be investigated further and replicated in future trials,we believe that viral-based therapies will someday soon be a standardpart of the cancer armamentarium."

About the "Terminator" Viruses

The"terminator" viruses have the potential to become effective treatmentsfor a wide range of tumors - such as ovarian, pancreatic, breast, brain(glioma), prostate, skin (melanoma) and colon cancer - because thevirus is constructed to exploit a characteristic of all solid cancers.However, clinical trials are necessary before such treatments can beapproved by the U.S. Food and Drug Administration and available forpatients.

These publications are a continuation of researchpublished in the Jan. 25, 2005 issue of PNAS, where the same researchteam, also led by Dr. Fisher, incorporated gene therapy into aspecially designed non-replicating virus to overcome one of the majorhurdles of gene therapy: its tendency to kill normal cells in theprocess of eradicating cancer cells. The virus eradicated prostatecancer cells in the lab and in animals, while leaving normal cellsunscathed.

The present cancer "terminator" viruses represent thenext generation of therapeutic viruses that permit replication uniquelyin cancer cells with simultaneous production of immune modulating andtoxic genes. These viruses effectively eliminate primary tumors anddistant tumors (metastases) without harming normal cells or tissues.

Dr.Fisher's cancer research team includes Columbia University MedicalCenter investigators: Drs. Zao-zhong Su (research scientist), DevanandSarkar (associate research scientist), Nicolaq Vozhilla (pathologytechnician), Eun Sook Park (pathology technician) and Pankaj Gupta(associate research scientist). Two scientists from VirginiaCommonwealth University in Richmond, Va. are also involved in theresearch: Mr. Aaron Randolph (graduate student) and Dr. KristofferValerie (professor).



Story Source:

The above story is based on materials provided by Columbia University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Columbia University Medical Center. "Columbia Scientists Develop Cancer Terminator Viruses." ScienceDaily. ScienceDaily, 20 September 2005. <www.sciencedaily.com/releases/2005/09/050920081309.htm>.
Columbia University Medical Center. (2005, September 20). Columbia Scientists Develop Cancer Terminator Viruses. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2005/09/050920081309.htm
Columbia University Medical Center. "Columbia Scientists Develop Cancer Terminator Viruses." ScienceDaily. www.sciencedaily.com/releases/2005/09/050920081309.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins