Featured Research

from universities, journals, and other organizations

Second-generation Antidepressants Very Similar But Have Different Side Effects

Date:
September 20, 2005
Source:
University of North Carolina at Chapel Hill
Summary:
Because clinical depression is so disabling and affects more than 16 percent of adults in the United States at some time in their lives, researchers have worked hard to develop more effective treatments. But how much better are the newer pharmaceuticals?

Manysecond-generation antidepressants, despite differences in drugclassification and cost, offer patients essentially the same benefitswith little variation in risks, University of North Carolina at ChapelHill researchers have found.

Such antidepressants includeselective serotonin reuptake inhibitors (SSRIs) and other drugs thataffect the activity of neurotransmitters in a selective way.

In apaper published online today (Sept. 19) and to be published in theOctober issue of the journal Annals of Internal Medicine, Dr. RichardA. Hansen and colleagues examined the effects of 10 commonly prescribedsecond-generation antidepressants. Those drugs included familiarbrand-name drugs such as Prozac, Zoloft, Effexor, Wellbutrin and Paxil.

Hansenis assistant professor of pharmacy at the UNC School of Pharmacy. Thestudy he led involved investigating the medications’ role in theinitial treatment of adults suffering from major depression bycombining and systematically analyzing data from 46 randomized,controlled trials.

Other authors, all at UNC, are Drs. GeraldGartlehner and Timothy S. Carey of the Cecil G. Sheps Center for HealthServices Research, Dr. Kathleen N. Lohr of the health policy andadministration department at the School of Public Health, and BradleyN. Gaynes of the School of Medicine’s psychiatry department. Carey,professor of medicine, directs the Sheps Center. Gartlehner isassociate director of the RTI-UNC Evidence-based Practice Center.

"Paststudies have compared the effectiveness of second-generationantidepressants with that of placebo or older treatments but have notsystematically evaluated how the second-generation agents compared toeach other," Hansen said. "Given the number of second-generationtreatments available, cost differences, widespread use and the generallack of consensus in how the drugs compare, our research can helppatients, clinicians and policy makers decide which drug is best."

Thebottom line was that one was about as good as another in terms ofeffectiveness, but the likelihood that patients experienced certainside effects differed between compounds, he said.

"Comparativeevidence on these drugs suggests that there are only minimaldifferences in efficacy, although some of the drugs come with anincreased risk of certain side effects," Hansen said. "Understandingthe likelihood of the side effects and matching this information withpatients’ lifestyle and preferences for anticipated side effects mayhelp improve drug treatment of depression.

"Although our studydid not specifically assess the impact of drug costs or differences indosing regimens on how patients fared, those factors also may beimportant determinants in drug selection," the scientist said. "That’sin the absence of patient preference or a clear choice for which agentis best for a given person."

Limitations of the study were thatpublished data from some trials was not as complete and comparable asresearchers would have preferred, Hansen said. Most data was fromtrials sponsored by drug companies, and questions remain as to howunbiased such studies are.

Support for the investigation came tothe Cecil G. Sheps Center for Health Services Research from the DrugEffectiveness Review Project, a collaborative program coordinated bythe Center for Evidence-Based Policy at the Oregon Health and ScienceUniversity.

In 2000, the economic burden of depression wasestimated to be $83.1 billion, Hansen said. Although drug treatmentdoes not work for all patients, drugs are usually considered the firstand potentially best treatment in part since primary care physiciansprescribe the majority of antidepressants in this country.


Story Source:

The above story is based on materials provided by University of North Carolina at Chapel Hill. Note: Materials may be edited for content and length.


Cite This Page:

University of North Carolina at Chapel Hill. "Second-generation Antidepressants Very Similar But Have Different Side Effects." ScienceDaily. ScienceDaily, 20 September 2005. <www.sciencedaily.com/releases/2005/09/050920081731.htm>.
University of North Carolina at Chapel Hill. (2005, September 20). Second-generation Antidepressants Very Similar But Have Different Side Effects. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2005/09/050920081731.htm
University of North Carolina at Chapel Hill. "Second-generation Antidepressants Very Similar But Have Different Side Effects." ScienceDaily. www.sciencedaily.com/releases/2005/09/050920081731.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins