Featured Research

from universities, journals, and other organizations

Study Finds Patients With Melanoma Are At Increased Risk For New Tumors

Date:
October 7, 2005
Source:
Memorial Sloan-Kettering Cancer Center
Summary:
Memorial Sloan-Kettering Cancer Center researchers have found that melanoma patients with a family history of melanoma and/or dysplastic nevi (abnormal moles) are at high risk of developing multiple primary melanomas (MPM). Researchers recommend more intensive follow up for these high-risk patients.

NEW YORK, October 4, 2005 - Memorial Sloan-Kettering Cancer Center(MSKCC) researchers have found that melanoma patients with a familyhistory of melanoma and/or dysplastic nevi (abnormal moles) are at highrisk of developing multiple primary melanomas (MPM). Researchersrecommend more intensive follow up for these high-risk patients. Theresults of this study, which will appear in the October 5 issue of theJournal of the American Medical Association (JAMA), emphasize theimportance of intensive dermatologic screenings for this population toidentify melanoma at its earliest stage.

"Since melanoma patients with a positive family history and/ordysplastic nevi were found to be at higher risk for multiple primarymelanomas, we recommend that these patients not only undergo morefrequent and intensive dermatologic screening, but also practiceself-exams," said Dr. Daniel Coit, co-leader of the MSKCC MelanomaDisease Management Team and senior author of the study.

The study is the first to utilize a multidisciplinary,single-institution database to identify the characteristics of patientsat risk for developing MPM. Researchers prospectively followed 4484melanoma patients treated at MSKCC. They found that:

385 patients (8.6 percent) had two or more primary melanomas, with an average of 2.3 melanomas per MPM patient;

78 percent of MPM patients had two primary melanomaswith 59 percent having had a second primary melanoma detected withinone year of the initial melanoma;

The estimated five-year risk of MPM issignificantly higher for melanoma patients with a positive familyhistory (18.5 percent) or dysplastic nevi (23.7 percent).

"The most striking increase we found was the likelihoodthat patients would develop a third primary melanoma in a relativelyshort period of time after they had developed a second primarymelanoma," said Cristina Ferrone, MD, second year surgical fellow atMSKCC and the study's lead author. "The risk of a third primary forthese patients was as high as15.6 percent after one year and over 30percent at five years." "While second and third primary melanomas aretreatable, this study shows the need for doctors and patients to bemore vigilant in dermatologic screening, self-examination and in closemonitoring of multiple atypical nevi," commented Alan Halpern, MD,Chief of the Dermatology Service at MSKCC and co-author of the study.

Melanoma is the most serious form of skin cancer. It is thefifth most common cancer among American men and the sixth most commonamong American women. In 2005, the rate of melanoma in the UnitedStates is predicted to rise by three percent to an estimated 59,580 newcases. This increasing incidence puts a greater portion of thepopulation at risk not only for one primary melanoma but also forsubsequent primary melanomas.

The study's other co-authors were Leah Ben Porat, Katherine S.Panageas, DrPH, Marianne Berwick, and Ami Patel. The melanoma databaseused for the study is a product of MSKCC's Melanoma Disease ManagementTeam. This is a multidisciplinary team of surgeons, medicaloncologists, dermatologists, and other medical professionals whospecialize in the diagnosis and treatment of melanoma.

###

Memorial Sloan-Kettering Cancer Center is the world's oldest andlargest institution devoted to prevention, patient care, research, andeducation in cancer. Our scientists and clinicians generate innovativeapproaches to better understand, diagnose, and treat cancer. Ourspecialists are leaders in biomedical research and in translating thelatest research to advance the standard of cancer care worldwide.


Story Source:

The above story is based on materials provided by Memorial Sloan-Kettering Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Memorial Sloan-Kettering Cancer Center. "Study Finds Patients With Melanoma Are At Increased Risk For New Tumors." ScienceDaily. ScienceDaily, 7 October 2005. <www.sciencedaily.com/releases/2005/10/051007100703.htm>.
Memorial Sloan-Kettering Cancer Center. (2005, October 7). Study Finds Patients With Melanoma Are At Increased Risk For New Tumors. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2005/10/051007100703.htm
Memorial Sloan-Kettering Cancer Center. "Study Finds Patients With Melanoma Are At Increased Risk For New Tumors." ScienceDaily. www.sciencedaily.com/releases/2005/10/051007100703.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins