Featured Research

from universities, journals, and other organizations

Model Predicts Risk Of Breast Cancer For Young Women Treated For Hodgkin Lymphoma

Date:
October 8, 2005
Source:
Journal of the National Cancer Institute
Summary:
Young women who are treated for Hodgkin lymphoma with chest radiation therapy have a high cumulative absolute risk of developing breast cancer later in life. This risk increases with age at end of follow-up, time since diagnosis, and radiation dose, according to a new study in the October 5 issue of the Journal of the National Cancer Institute.

Young women who are treated for Hodgkin lymphoma with chestradiation therapy have a high cumulative absolute risk of developingbreast cancer later in life. This risk increases with age at end offollow-up, time since diagnosis, and radiation dose, according to a newstudy in the October 5 issue of the Journal of the National CancerInstitute.

Related Articles


Due to advances in the treatment of Hodgkin lymphoma,there are now many long-term survivors who are at risk for thedevelopment of secondary cancers that frequently reflect the late sideeffects of treatment. Second primary cancers are the leading cause ofdeath among long-term survivors, and breast cancer is the most commonsecondary cancer in female Hodgkin lymphoma survivors.

Toestimate the future cumulative absolute risk of breast cancer for youngwomen treated for Hodgkin lymphoma, Lois B. Travis, M.D., of theNational Cancer Institute, and colleagues analyzed data from acase-control study within an international population-based cohort of3,817 female 1-year survivors of Hodgkin lymphoma who had beendiagnosed at age 30 or younger between 1965 and 1994.

Thecumulative absolute risk of developing breast cancer increased with ageat end of follow-up, time since diagnosis, and radiation dose. Forexample, a woman who was treated for Hodgkin lymphoma at age 20 with achest radiation dose of at least 40 Gy without alkylating agents wouldhave a 0.4% risk of developing breast cancer by age 30, a 4.9% risk byage 40, and a 19.1% risk by age 50. By comparison, for white women inthe general population, the absolute risks of breast cancer from age 20to ages 30, 40, and 50 are, respectively, 0.04%, 0.5%, and 2.0%.

"However,it should always be noted that the gains in long-term survival providedby successful radiotherapy and chemotherapy outweigh the associatedrisks of breast cancer and other late sequelae. Moreover, currentmodifications in treatment will likely result in lower risks of breastcancer in the future," the authors write.

In an editorial, Dan L.Longo, M.D., of the National Institute on Aging, questions thecontinued routine use of radiation therapy for the treatment of Hodgkindisease when alternative approaches, such as combination chemotherapyalone, have similar success in curing the disease without the magnitudeof late fatal complications. "We need to stop exposing women to therisk of subsequent breast cancer (and other malignancies and heartdisease) by needlessly using radiation therapy as a component of theirHodgkin disease treatment," he writes. "A Pyrrhic victory in theabsence of reasonable alternative ways to accomplish the goal can betragic but necessary; a Pyrrhic victory that could be avoided whilestill accomplishing the goal is just foolish."

###

Citations:
#Article: Travis LB, Hill D, Dores GM, Gospodarowicz M, van Leeuwen FE,Holowaty E, et al. Cumulative Absolute Breast Cancer Risk for YoungWomen Treated for Hodgkin Lymphoma. J Natl Cancer Inst 2005;97:1428
# Editorial: Longo DL. Radiation Therapy in Hodgkin Disease: Why Risk A Pyrrhic Victory? J Natl Cancer Inst 2005;97:1394

Note:The Journal of the National Cancer Institute is published by OxfordUniversity Press and is not affiliated with the National CancerInstitute. Visit the Journal online at http://jncicancerspectrum.oxfordjournals.org/.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Model Predicts Risk Of Breast Cancer For Young Women Treated For Hodgkin Lymphoma." ScienceDaily. ScienceDaily, 8 October 2005. <www.sciencedaily.com/releases/2005/10/051008203718.htm>.
Journal of the National Cancer Institute. (2005, October 8). Model Predicts Risk Of Breast Cancer For Young Women Treated For Hodgkin Lymphoma. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2005/10/051008203718.htm
Journal of the National Cancer Institute. "Model Predicts Risk Of Breast Cancer For Young Women Treated For Hodgkin Lymphoma." ScienceDaily. www.sciencedaily.com/releases/2005/10/051008203718.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins