Featured Research

from universities, journals, and other organizations

Midlife Obesity May Be Associated With Risk Of Dementia And Alzheimer's Disease

Date:
October 11, 2005
Source:
JAMA and Archives Journals
Summary:
Individuals who were obese at midlife had an increased risk for dementia later in life compared to individuals of normal weight, according to an article in the October issue of Archives of Neurology, one of the JAMA/Archives journals.

Related Articles


Obesity is onthe rise all over the world and is related to vascular diseases, whichmay be linked to dementia and Alzheimer's disease (AD), according tobackground information in the article. However, the link betweenobesity and dementia risk has not been extensively studied andlong-term follow-up studies performed thus far have yielded somewhatconflicting results.

Miia Kivipelto, M.D., Ph.D., from theKarolinska Institutet, Stockholm, Sweden, and colleagues re-examinedparticipants in the Cardiovascular Risk Factors, Aging, and Dementia(CAIDE) study to investigate the relationship between midlife body massindex (BMI; weight in kilograms divided by square of height in meters)and a group of vascular risk factors, and subsequent dementia and AD.Participants in the CAIDE study were derived from random, population-based samples previously studied in a survey carried out in 1972, 1977,1982, or 1987. After an average follow-up of 21 years, 1,449individuals aged 65 to 79 years participated in the 1998 reexamination.

Theresearchers discovered dementia and AD to be prevalent significantlymore among those with a higher midlife BMI. One-third of theparticipants had a BMI lower than 25 (normal weight), half had a BMIfrom 25 to 30 (overweight), and the remaining 16 percent had a BMIhigher than 30 (obese) at midlife. A history of heart attack anddiabetes mellitus were more prevalent in those with the highest midlifeBMI . Midlife obesity, high systolic blood pressure, and high totalcholesterol level were all significant risk factors for late-lifedementia. Being overweight in midlife was not significantly associatedwith dementia later in life.

"This study shows that obesity atmidlife may increase the risk of dementia and AD later in life," theauthors write. "… midlife obesity, high SBP, and high total cholesterollevel were all significant risk factors for dementia, each of themincreasing the risk around two times. Clustering of these vascular riskfactors increased the risk of dementia and AD in an additive manner sothat persons with all three risk factors had around a six times higherrisk for dementia than persons having no risk factors."

###

(Arch Neurol. 2005; 62: 1556 – 1560. Available pre-embargo to the media at www.jamamedia.org.)

Editor'sNote: This study was supported by the Aging Program of the Academy ofFinland, Helsinki; EVO grants from the Kuopio University Hospital,Kupio, Finland; Academy of Finland grants (Dr. Kivipelto); and theGamla Tjδnarinnor Foundation (Dr. Kivipelto), grant from the SwedishCoucil for Working Life and Scoial Research, and the SADF(Insamligsstiftelsen fφr Alzheimeroch Demensforskning) (co-author, Ms.Ngandu), Stockholm.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Midlife Obesity May Be Associated With Risk Of Dementia And Alzheimer's Disease." ScienceDaily. ScienceDaily, 11 October 2005. <www.sciencedaily.com/releases/2005/10/051011073139.htm>.
JAMA and Archives Journals. (2005, October 11). Midlife Obesity May Be Associated With Risk Of Dementia And Alzheimer's Disease. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2005/10/051011073139.htm
JAMA and Archives Journals. "Midlife Obesity May Be Associated With Risk Of Dementia And Alzheimer's Disease." ScienceDaily. www.sciencedaily.com/releases/2005/10/051011073139.htm (accessed October 24, 2014).

Share This



More Mind & Brain News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) — A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) — Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) — We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins