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Jefferson Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack

Date:
November 20, 2005
Source:
Thomas Jefferson University Hospital
Summary:
A drug has been shown to provide some protection to the heart from injury even if given as much as 24 hours after a heart attack, Jefferson Medical College researchers report. Darbepoietin, a long-acting cousin of erythropoietin (EPO), offered significant protection to heart tissue from injury from ischemia, and even helped improve cardiac function.
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A drug has been shown to provide some protection to the heart from injury even if given as much as 24 hours after a heart attack, Jefferson Medical College researchers report.

Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his co-workers knew that the drug Darbepoietin alpha would protect the ischemic heart. Darbepoietin is a long-acting cousin of erythropoietin (EPO), which has been shown to offer some protection to the heart from injury from ischemia, or a lack of oxygen. In previous studies, Dr. Koch had given EPO at the time of simulated heart attack in an another animal model, and found it protected the animals.

But in further studies, Dr. Koch gave Darbepoietin to animals at the time of ischemia and heart attack, one to two hours after, and 24 hours later. In each case, the scientists saw that the drug offered significant protection to heart tissue, and even helped improve cardiac function.

Dr. Koch believes the results “may be quickly translated into clinical trials.” He and his team present their findings on November 16, 2005 at the American Heart Association’s Scientific Sessions 2005 in Dallas.


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The above post is reprinted from materials provided by Thomas Jefferson University Hospital. Note: Materials may be edited for content and length.


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Thomas Jefferson University Hospital. "Jefferson Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack." ScienceDaily. ScienceDaily, 20 November 2005. <www.sciencedaily.com/releases/2005/11/051120121557.htm>.
Thomas Jefferson University Hospital. (2005, November 20). Jefferson Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack. ScienceDaily. Retrieved September 2, 2015 from www.sciencedaily.com/releases/2005/11/051120121557.htm
Thomas Jefferson University Hospital. "Jefferson Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack." ScienceDaily. www.sciencedaily.com/releases/2005/11/051120121557.htm (accessed September 2, 2015).

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