Featured Research

from universities, journals, and other organizations

Mayo Clinic Researchers Redefining How Heart Functions

Date:
December 4, 2005
Source:
Mayo Clinic
Summary:
Contrary to the widely accepted explanation that the human heart is simply a pump, Mayo Clinic researchers have uncovered novel findings on how cardiac muscle operates. The findings will appear in the Jan. 3, 2006, issue of the Journal of the American College of Cardiology.

"Redefining how the heart functions is one of the first steps that could lead to revolutionary approaches to treating patients who have heart failure - 5 million and growing in the U.S. - or better yet, preventing the heart failure from developing," says Bijoy Khandheria, M.D., chair of the Division of Cardiology at Mayo Clinic in Arizona and one of the co-authors of the study.

Related Articles


The heart is often thought as a "piston pump." Contraction (systole) occurs when the heart moves blood from its left ventricular cavity into the body's circulatory system, and relaxation (diastole) is when the heart fills with new blood.

According to Marek Belohlavek, M.D., Ph.D., senior author of the study, "This research focuses on the cardiac left ventricle. Results show that the left ventricle ejects blood into the body's blood vessels through well synchronized electrical and mechanical waves traveling from the heart's tip (apex) towards the base of the heart."

Dr. Belohlavek, a scientist at Mayo Clinic in Rochester, Minn., engaged in more accurately defining how the heart functions, explains, "Relaxation (diastole) is much more important than we previously realized. Diastole is actually comprised of an active and passive expansion phases, which efficiently fill the pumping chamber with blood. The newest discovery is the fact that there is an additional contribution to the active relaxation phase by muscle layers close to the outer surface of the pumping chamber."

Partho Sengupta, M.D., lead author of the study who designed the project under the mentorship of Drs. Belohlavek and Khandheria, notes further: "By a brief shortening, cardiac muscle in these outer layers helps to 'unwrap' the rest of the left ventricle after each twisting contraction. we plan to study whether impairment of this active 'unwrapping' in some heart diseases could contribute to left ventricular failure -- and, if yes, we hope to find ways to prevent such impairment."

###

Other Mayo Clinic researchers who participated in the study are: Josef Korinek, M.D.; Jianwen Wang, M.D.; Arshad Jahangir, M.D.; and James B. Seward, M.D.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Researchers Redefining How Heart Functions." ScienceDaily. ScienceDaily, 4 December 2005. <www.sciencedaily.com/releases/2005/12/051203122102.htm>.
Mayo Clinic. (2005, December 4). Mayo Clinic Researchers Redefining How Heart Functions. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2005/12/051203122102.htm
Mayo Clinic. "Mayo Clinic Researchers Redefining How Heart Functions." ScienceDaily. www.sciencedaily.com/releases/2005/12/051203122102.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

85 Killed in Niger by Meningitis Since Start of Year

85 Killed in Niger by Meningitis Since Start of Year

AFP (Apr. 24, 2015) A meningitis outbreak in Niger has killed 85 people since the start of the year prompting authorities to close schools in the capital Niamey until Monday. Video provided by AFP
Powered by NewsLook.com
C-Section Births a Trend in Brazil

C-Section Births a Trend in Brazil

AFP (Apr. 24, 2015) More than half of Brazil&apos;s babies are born via cesarean section, as mothers and doctors opt for a faster and less painful experience despite the health risks. Duration: 02:02 Video provided by AFP
Powered by NewsLook.com
Anti-Malaria Jab Hope

Anti-Malaria Jab Hope

Reuters - News Video Online (Apr. 24, 2015) The world&apos;s first anti-malaria vaccine could get the go-ahead for use in Africa from October if approved by international regulators. Paul Chapman reports. Video provided by Reuters
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins