Featured Research

from universities, journals, and other organizations

Supersized 'Island' Of Resistance Genes Discovered In An Infectious Bacterium

Date:
January 14, 2006
Source:
Public Library Of Science
Summary:
Researchers have discovered a cluster of 45 genes coding for antibacterial drug resistance in the bacterium, Acinetobacter baumannii, a major cause of hospital-acquired infections worldwide. The study was reported in the open-access journal PLoS Genetics.

Researchers have discovered a cluster of 45 genes coding for antibacterial drug resistance in the bacterium, Acinetobacter baumannii, a major cause of hospital-acquired infections worldwide. The study was reported in the open-access journal PLoS Genetics."We expected to find resistance genes," said lead author, Pierre-Edouard Fournier, researcher at the Structural and Genomic Information Laboratory at France's National Center for Scientific Research (CNRS). "But the grouping of most of these genes within a single genomic island was totally unexpected." The resistance island--a group of resistance genes clustered close together on a chromosome--is the largest discovered to date.

Related Articles


The research team also discovered new resistance genes. "We were surprised to discover 19 new resistance genes that escaped the scrutiny of the large number of laboratories already working on multi-drug resistant A. baumannii throughout the world. This is a demonstration of the efficiency of the whole genome approach in characterizing new pathogens," said Jean-Michel Claverie, senior author of the report and Director of the Structural and Genomic Information Laboratory at CNRS.

This bacterium acquires resistance genes quickly--just thirty years ago it was completely susceptible to antibiotics and now it is resistant to a wide-range of antibiotics.

"A. baumannii is exceptionally prone to pick up foreign DNA from other bacteria," Claverie said. The study traced the origin of many resistance genes to other bacteria, including Salmonella, indicating frequent genetic swapping between bacteria.

Resistance genes are usually located on small auxiliary circles of DNA called plasmids that can be exchanged with other individuals. But in A. baumannii, resistance genes were incorporated into the main chromosome, not the plasmids, according to the study.

"It is like the A. baumannii genome is 'anticipating' any antibacterial challenge by setting up some kind of easily accessible 'shelves' to store the antibacterial resistances genes as they become needed and are available in the environment," Claverie said.

The research team compared the entire genomes of two A. baumannii strains, one completely susceptible to antibiotics and one highly resistant.

"This is the first study of its kind to study the resistance mechanisms of a bacterial strain by whole genome sequencing," said Fournier. "Our strategy of sequencing the whole genome of a bacterial strain with specific features is valuable and fast."

Resistant A. baumannii has become a major public health concern worldwide. Recently, a high incidence of resistant A. baumannii was reported in US Army service members injured in Afghanistan and Iraq. In France, the resistant strain is widespread in 54 healthcare facilities, where 26% of infected patients die.

"Less than 2 years after the start of the French epidemic episode, we found the complete genome ID of the microbe involved and developed a better understanding of what to expect for the future, in terms of new antibiotic resistance," Claverie said. "This work will guide a future international effort on identifying all major A. baumannii resistant strains throughout the world, and help follow the emergence of new strains and understand their mode of evolution."


Story Source:

The above story is based on materials provided by Public Library Of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library Of Science. "Supersized 'Island' Of Resistance Genes Discovered In An Infectious Bacterium." ScienceDaily. ScienceDaily, 14 January 2006. <www.sciencedaily.com/releases/2006/01/060114153108.htm>.
Public Library Of Science. (2006, January 14). Supersized 'Island' Of Resistance Genes Discovered In An Infectious Bacterium. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2006/01/060114153108.htm
Public Library Of Science. "Supersized 'Island' Of Resistance Genes Discovered In An Infectious Bacterium." ScienceDaily. www.sciencedaily.com/releases/2006/01/060114153108.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

500 Snakes Surprise Construction Workers In Canada

500 Snakes Surprise Construction Workers In Canada

Newsy (Mar. 2, 2015) Hundreds of snakes, disturbed by a construction project, were relocated to a wildlife rescue association in Canada. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
Zookeepers Copy Animal Poses In Hilarious Viral Photos

Zookeepers Copy Animal Poses In Hilarious Viral Photos

Buzz60 (Mar. 2, 2015) Zookeepers at the Symbio Wildlife Park in Helensburgh, Australia decided to take some of their favorite animal photos and recreate them by posing just like the animals. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com
Heavy Toll as Australian Farmers Struggle Through Drought

Heavy Toll as Australian Farmers Struggle Through Drought

AFP (Mar. 2, 2015) Mounting debts, despair and forced repossessions are taking a heavy toll on farmers in parts of Australia suffering from its worst drought in 100 years. Duration: 02:16 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins