Featured Research

from universities, journals, and other organizations

Antipsychotic Drug May Block Addiction, Researchers Find

Date:
February 13, 2006
Source:
University of Illinois at Chicago
Summary:
Researchers at the University of Illinois at Chicago have discovered that a long-approved oral antipsychotic drug can stop the addictive properties of opioid painkillers in mice.

Researchers at the University of Illinois at Chicago have discovered that a long-approved oral antipsychotic drug can stop the addictive properties of opioid painkillers in mice.

Related Articles


The researchers injected a small dose (half a milligram) of trifluoperazine -- used in the treatment of mental diseases such as schizophrenia -- into laboratory mice hooked on morphine. After a few hours their addiction was gone, said Z. Jim Wang, assistant professor of pharmacology in the UIC College of Pharmacy.

This is the first time any study has shown the anti-addictive property of trifluoperazine, Wang said.

"From studies conducted in the 1970s and 1980s, we know that trifluoperazine inhibits calmodulin," Wang said, a molecule that is required for the activation of an enzyme called calcium/calmodulin-dependent protein kinase-2. "In previous studies we performed at UIC, we know that CaMK-2 plays an important role in the generation and maintenance of opioid tolerance," he said. Tolerance is a hallmark of drug dependence.

"Trifluoperazine targets this pathway, which then stops the addiction," Wang said. "When this occurs, you can still use a relatively low dose of the painkiller to achieve fairly good pain control and no drug dependence."

Opioids such as morphine are commonly used in pain management, but many patients are wary of taking them because of concerns over addiction or adverse side effects.

The study, which began early last year and was supported in part by grants from the National Institutes of Health and the American Foundation for Pharmaceutical Education, is published in the journal Neuroscience Letters. It is now available online and will be printed later this month.

Other researchers involved in the study were graduate student Lei Tang and post-doctoral researcher Pradeep Shukla, both of the UIC College of Pharmacy.



Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "Antipsychotic Drug May Block Addiction, Researchers Find." ScienceDaily. ScienceDaily, 13 February 2006. <www.sciencedaily.com/releases/2006/02/060213092323.htm>.
University of Illinois at Chicago. (2006, February 13). Antipsychotic Drug May Block Addiction, Researchers Find. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2006/02/060213092323.htm
University of Illinois at Chicago. "Antipsychotic Drug May Block Addiction, Researchers Find." ScienceDaily. www.sciencedaily.com/releases/2006/02/060213092323.htm (accessed October 24, 2014).

Share This



More Mind & Brain News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Working Mother Getaway: Beaches Turks & Caicos

Working Mother Getaway: Beaches Turks & Caicos

Working Mother (Oct. 22, 2014) Feast your eyes on this gorgeous family-friendly resort. Video provided by Working Mother
Powered by NewsLook.com
What Your Favorite Color Says About You

What Your Favorite Color Says About You

Buzz60 (Oct. 22, 2014) We all have one color we love to wear, and believe it or not, your color preference may reveal some of your character traits. In celebration of National Color Day, Krystin Goodwin (@kyrstingoodwin) highlights what your favorite colors may say about you. Video provided by Buzz60
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins