Featured Research

from universities, journals, and other organizations

Faulty Immune-priming Cells Start Autoimmunity

Date:
February 27, 2006
Source:
Baylor College of Medicine
Summary:
The failure of programming that sparks the death of dendritic cells -- those that activate the immune system -- can initiate autoimmune disease, said researchers from Baylor College of Medicine in a report that appears in the current issue of the journal Science.

The failure of programming that sparks the death of dendritic cells -- those that activate the immune system -- can initiate autoimmune disease, said researchers from Baylor College of Medicine in a report that appears in the current issue of the journal Science.

The problem begins with a process called programmed cell death or apoptosis, said Dr. Jin Wang, assistant professor of immunology at Baylor College of Medicine. Mice bred to have a defect in apoptosis of their dendritic cells went on to develop autoimmune disease, he said.

"This suggests that defective apoptosis of dendritic cells can be a critical component of autoimmune diseases," said Wang.

Autoimmune diseases, such as juvenile diabetes and lupus, result when the immune system begins attacking the body's own tissues rather than foreign bodies.

"We knew that autoimmunity in general can be caused when dendritic cells are unchecked, either by programmed cell death or overactivation," said Wang.

"Dendritic cells are the initiators of immunity," said Wang.

They do this by showing or presenting foreign antigens from invading bacteria or viruses to the immune system, which then activates lymphocytes to attack.

Previously, many people thought autoimmunity occurred through apoptosis because of accumulating lymphocytes or white blood cells -- key elements of the immune system.

"If they didn't die, we thought they would start to accumulate and do damage to the body's own tissues," he said. However, at least eight studies that suppressed programmed cell death in lymphocytes did not induce autoimmune disease in animals.

In the future, Wang said, he and his colleagues plan to fill in the gaps between what happens when apoptosis is hindered in the dendritic cells and the occurrence of autoimmune disease.

###

Others who participated in this research include: Drs. Min Chen, Li Huang and Hector Sandoval of BCM, and Drs. Yui-Hsi Wang, Yihong Wang, and Yong-Jun Liu of The University of Texas M.D. Anderson Cancer Center.

Funding for this project came from the Cancer Research Institute, American Society of Hematology, the National Institutes of Health and a Ruth L. Kirschstein National Research Service Award.


Story Source:

The above story is based on materials provided by Baylor College of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Baylor College of Medicine. "Faulty Immune-priming Cells Start Autoimmunity." ScienceDaily. ScienceDaily, 27 February 2006. <www.sciencedaily.com/releases/2006/02/060227185023.htm>.
Baylor College of Medicine. (2006, February 27). Faulty Immune-priming Cells Start Autoimmunity. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2006/02/060227185023.htm
Baylor College of Medicine. "Faulty Immune-priming Cells Start Autoimmunity." ScienceDaily. www.sciencedaily.com/releases/2006/02/060227185023.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins