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Scientists Gain New Understanding Of Age-related Depression And Dementia

Date:
February 28, 2006
Source:
University of Edinburgh
Summary:
Researchers at the University of Edinburgh have identified for the first time a certain area of the brain which can shrink in old age and cause depression and Alzheimer's disease. The scientists believe the shrinkage may be caused by high levels of stress hormones.

Researchers at the University of Edinburgh have identified for the first time a certain area of the brain which can shrink in old age and cause depression and Alzheimer's disease. The scientists believe the shrinkage may be caused by high levels of stress hormones.

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They examined the size of a special region of the brain, the anterior cingulate cortex, that might be involved in controlling stress hormones. In a significant discovery, scientists found that people with a smaller anterior cingulate cortex had higher levels of stress hormones.

Doctors analysed stress hormone levels and brain volume in two groups of ten healthy male volunteers aged 65-70 for the study. Lead author Dr Alasdair MacLullich said: "Doctors have known for several years that ageing, and certain diseases common in ageing like Alzheimer's disease and depression, can be associated with shrinkage of the brain, but this is the first time we have been able to show that increased levels of stress hormones may cause shrinkage of this critical area of the brain.

"This is an important new finding because the anterior cingulate cortex shows damage in ageing, depression, and Alzheimer's disease, and stress hormones are often high in these conditions. The discovery deepens doctors' understand of ageing, depression and Alzheimer's diseases, and will help in the development of treatments based on reducing high levels of stress hormones."



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The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


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University of Edinburgh. "Scientists Gain New Understanding Of Age-related Depression And Dementia." ScienceDaily. ScienceDaily, 28 February 2006. <www.sciencedaily.com/releases/2006/02/060228090104.htm>.
University of Edinburgh. (2006, February 28). Scientists Gain New Understanding Of Age-related Depression And Dementia. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2006/02/060228090104.htm
University of Edinburgh. "Scientists Gain New Understanding Of Age-related Depression And Dementia." ScienceDaily. www.sciencedaily.com/releases/2006/02/060228090104.htm (accessed October 24, 2014).

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