Featured Research

from universities, journals, and other organizations

Nicotine Can Inhibit Lung Cancer Chemotherapy

Date:
April 3, 2006
Source:
H. Lee Moffitt Cancer Center And Research Institute
Summary:
Nicotine can prevent chemotherapeutic drugs such as taxol from killing lung cancer cells, researchers at the H. Lee Moffitt Cancer Center and Research Institute report. While nicotine itself is not a carcinogen, it can influence biological pathways that help promote tumor growth.

Nicotine can prevent chemotherapeutic drugs such as taxol from killing lung cancer cells, researchers at the H. Lee Moffitt Cancer Center and Research Institute report. While nicotine itself is not a carcinogen, it can influence biological pathways that help promote tumor growth.

Srikumar Chellappan, Ph.D. and colleagues tested whether nicotine’s influence could affect the performance of three standard lung cancer drugs: gemcitabine, cisplatin, and taxol. They found that in a variety of lung cancer cell lines, the addition of a small amount of nicotine, what would be present in the blood of an average smoker, inhibited these drugs’ ability to kill the cancer cells. Nicotine protected the cells by upregulating two genes, XIAP and survivin, which act to prevent cells from undergoing apoptosis, or programmed cell death. When the authors silenced the expression of either gene, nicotine’s protective effect was eliminated.

"While this research is enlightening the best thing is to stay away from nicotine in all forms and use behavioral smoking cessation therapies as a viable alternative,” says Chellappan, associate professor of the Drug Discovery Program.

Clinical studies have shown that cancer patients who continue to smoke during chemotherapy have lower response to treatment, and now these findings suggest that even people who quit smoking but use nicotine supplements such as patches or gum may not respond as well to drug treatment.

Chellappan’s findings will be publishing online this week in the journal PNAS (Proceedings of the National Academy of Sciences). His research will be presented at the annual meeting of the American Association for Cancer Research in Washington, D.C. April 2.

In 2001, the National Cancer Institute awarded Moffitt the status of a Comprehensive Cancer Center in recognition of its excellence in research and contributions to clinical trials, prevention and cancer control. Additionally, Moffitt is a member of the National Comprehensive Cancer Network, a prestigious alliance of the country’s leading cancer centers, and is listed in U.S. News & World Report as one of the top cancer hospitals in America. Moffitt’s sole mission is to contribute to the prevention and cure of cancer.


Story Source:

The above story is based on materials provided by H. Lee Moffitt Cancer Center And Research Institute. Note: Materials may be edited for content and length.


Cite This Page:

H. Lee Moffitt Cancer Center And Research Institute. "Nicotine Can Inhibit Lung Cancer Chemotherapy." ScienceDaily. ScienceDaily, 3 April 2006. <www.sciencedaily.com/releases/2006/04/060403134158.htm>.
H. Lee Moffitt Cancer Center And Research Institute. (2006, April 3). Nicotine Can Inhibit Lung Cancer Chemotherapy. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2006/04/060403134158.htm
H. Lee Moffitt Cancer Center And Research Institute. "Nicotine Can Inhibit Lung Cancer Chemotherapy." ScienceDaily. www.sciencedaily.com/releases/2006/04/060403134158.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins