Featured Research

from universities, journals, and other organizations

Direct Link Between High Cholesterol And Prostate Cancer Found

Date:
April 12, 2006
Source:
European Society for Medical Oncology
Summary:
Researchers from Italy have found what they believe to be the first direct link between high cholesterol levels and prostate cancer. A new study, published on-line (Wednesday 12 April) in Annals of Oncology shows a statistically significant direct relationship between the two conditions.

Researchers from Italy have found what they believe to be the first direct link between high cholesterol levels and prostate cancer.

A possible association has been suggested before but evidence has been limited. This new study, published in Annals of Oncology[1] shows a statistically significant direct relationship between the two conditions.

Lead author Dr Francesca Bravi, an epidemiologist from the Istituto di Ricerche Farmacologiche Mario Negri in Milan, said: "Although the study relied on participants' self-reported medical conditions, the absence of an association between prostate cancer and about 10 other medical conditions we investigated indicates that the relationship we found between prostate cancer and high cholesterol appears to be a real one."

The research team worked on data from a case-control study carried out in four Italian areas between 1991 and 2002, involving 1,294 men under age 75 with prostate cancer and 1,451 matched controls admitted to the same hospitals with acute non-cancerous conditions.

All cases and controls were interviewed in hospital by trained interviewers using wide-ranging structured questionnaires. These included a problem-oriented section on patients' medical history covering about 10 non-cancerous conditions, including hypercholesterolaemia (high cholesterol) and gallstones.

Dr Bravi said: "We found that, after allowing for any potential confounding factors, men with prostate cancer were around 50% more likely to have had high cholesterol levels[2] than our non-prostate cancer controls. The association was somewhat stronger for men whose high cholesterol levels had been diagnosed before they were 50 and for men over 65, where there was an 80% greater likelihood of high cholesterol levels. We also found that prostate cancer patients were 26% more likely to have suffered from gallstones than our controls, with an apparently higher relationship in thinner men. Although that figure was not statistically significant, gallstones are often related to high cholesterol levels. To our knowledge there have been no previous studies reporting any relationship between gallstones and prostate cancer."

Co-author Dr Cristina Bosetti, a senior epidemiologist and biostatistician at the same institute, explained: "Androgens -- hormones that have a role in prostate tissue and cancer -- are synthesised from cholesterol, suggesting a possible biological relationship between high cholesterol and prostate cancer. Gallstones are related to high cholesterol levels as well and are often composed of cholesterol. So, the direct relationship we found between gallstones and prostate cancer, while it was not statistically significant, suggests a similar biological mechanism may explain the link."

This study had relied on participant's self-reporting medical conditions: the researchers believe that their results should be confirmed by further studies, including prospective investigations with reliable measured cholesterol levels.

Dr Bosetti concluded: "There are some laboratory data suggesting statins may have preventive potential against prostate cancer and our results do give an indirect suggestion that statins may help in lowering prostate cancer risk. However, studies to date on cholesterol-lowering statins and prostate cancer have been limited and inconclusive."

[1] Self-reported history of hypercholesterolaemia and gallstones and the risk of prostate cancer. Annals of Oncology. doi:10.1093/annonc/mdi080.

[2] Hypercholesterolaemia (high cholesterol levels): In this study hypercholesterolaemia was classified as any cholesterol over the normal level (>200 mg/dl or approximately 5 mmol/l).


Story Source:

The above story is based on materials provided by European Society for Medical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

European Society for Medical Oncology. "Direct Link Between High Cholesterol And Prostate Cancer Found." ScienceDaily. ScienceDaily, 12 April 2006. <www.sciencedaily.com/releases/2006/04/060411231430.htm>.
European Society for Medical Oncology. (2006, April 12). Direct Link Between High Cholesterol And Prostate Cancer Found. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2006/04/060411231430.htm
European Society for Medical Oncology. "Direct Link Between High Cholesterol And Prostate Cancer Found." ScienceDaily. www.sciencedaily.com/releases/2006/04/060411231430.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins