Featured Research

from universities, journals, and other organizations

Abnormal Glucose Metabolism May Contribute To Chronic Nerve Disorder

Date:
June 19, 2006
Source:
JAMA and Archives Journals
Summary:
Abnormal glucose metabolism, which occurs when the body has difficulty processing sugar (glucose) into energy, is twice as common among patients with chronic nerve dysfunction of unknown cause than among the general population and may be a risk factor for the condition, according to a study posted online today that will appear in the August 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals.

Abnormal glucose metabolism, which occurs when the body has difficulty processing sugar (glucose) into energy, is twice as common among patients with chronic nerve dysfunction of unknown cause than among the general population and may be a risk factor for the condition, according to a study posted online today that will appear in the August 2006 print issue of Archives of Neurology, one of the JAMA/Archives journals.

Many older adults experience nerve disorders known as neuropathy, some of which are characterized by symptoms of "burning feet" and other unpleasant sensations in the lower leg, according to background information in the article. Diabetes, genetic disorders, exposure to toxic substances and a condition called amyloidosis in which extra protein-based substances accumulate in the body tissues can all cause neuropathy, but many cases do not have an easily identifiable underlying cause. When laboratory tests cannot determine the cause, the condition is known as chronic idiopathic axonal polyneuropathy; a cause is eventually found in only 7 to 30 percent of these cases.

Charlene Hoffman-Snyder, M.S.N., N.P.-B.C., Mayo Clinic, Arizona, and colleagues identified 100 consecutive patients (60 women and 40 men) with chronic idiopathic axonal polyneuropathy who were evaluated between January 2003 and January 2005. Patients underwent a complete neurological evaluation and had a fasting plasma glucose test, which measures the levels of glucose in the blood after eight hours of not eating, and a two-hour oral glucose tolerance test, which determines how well the body processes glucose by drawing blood two hours after fasting patients ingest a dose of glucose. "The fasting plasma glucose level alone does not always identify patients with impaired glucose tolerance and neither does the two-hour oral glucose tolerance test always detect patients with impaired glucose metabolism," the authors write. "Both tests are, however, useful to detect hyperglycemia [high blood sugar] and the consequences of disordered glucose metabolism."

According to the two-hour oral glucose tolerance test, 62 patients (62 percent) with neuropathy had abnormal fasting glucose metabolism, including 24 with undiagnosed diabetes. (This compares with 33 percent of patients of similar ages in the general population with abnormal glucose metabolism as previously estimated by the Centers for Disease Control and Prevention in other published reports.) The results of the current study suggest that abnormal glucose metabolism may be a risk factor for neuropathy.

"Conventional thinking among diabetologists is that diabetic polyneuropathies are the result of prolonged hyperglycemia," the authors write. "Like previous studies, this investigation supports the hypothesis that distal axonal polyneuropathies may occur in much earlier stages of abnormal glucose metabolism than previously thought. Recent studies suggest that the neuropathy associated with impaired glucose tolerance may be milder than neuropathies traditionally associated with diabetes mellitus and may be the earliest detectable sign of abnormal glucose metabolism."

(Arch Neurol. 2006; 63: (doi: 10.1001/archneur.63.8.noc50336). Available pre-embargo to the media at www.jamamedia.org.)


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Cite This Page:

JAMA and Archives Journals. "Abnormal Glucose Metabolism May Contribute To Chronic Nerve Disorder." ScienceDaily. ScienceDaily, 19 June 2006. <www.sciencedaily.com/releases/2006/06/060618235033.htm>.
JAMA and Archives Journals. (2006, June 19). Abnormal Glucose Metabolism May Contribute To Chronic Nerve Disorder. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2006/06/060618235033.htm
JAMA and Archives Journals. "Abnormal Glucose Metabolism May Contribute To Chronic Nerve Disorder." ScienceDaily. www.sciencedaily.com/releases/2006/06/060618235033.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins