Featured Research

from universities, journals, and other organizations

Three Human Gene Variants Appear To Influence Tuberculosis Susceptibility

Date:
June 22, 2006
Source:
Harvard School of Public Health
Summary:
Three variations of a human gene appear to impact human tuberculosis susceptibility, providing insight into why some patients infected with the Mycobacterium tuberculosis pathogen develop the full-blown disease and others do not.

Three variations of a human gene appear to impact human tuberculosis susceptibility, providing insight into why some patients infected with the Mycobacterium tuberculosis pathogen develop the full-blown disease and others do not. The finding is published in the online early edition of the Proceedings of the National Academy of Sciences (PNAS) for the week of June 19-23. The paper additionally describes how the association of two of the gene variants with the disease has been replicated.

Related Articles


Approximately one-third of the world's population is thought to be infected with the M. tuberculosis pathogen, yet only about 10 percent becomes ill with the active disease. Researchers suspect that a variety of factors interplay to determine who develops the full-blown disease. For example, in February 2006 Harvard School of Public Health (HSPH) researchers were part of a team that identified a mechanism that explains why people of African descent may be more vulnerable to the disease.

Now HSPH Associate Professor Igor Kramnik is part of a team led by Professor Adrian V.S. Hill of Oxford University that has identified three variations of a human gene associated with tuberculosis susceptibility. The lead author on the paper is Kerrie Tosh of the Wellcome Trust Centre for Human Genetics in the U.K.

Kramnik and his colleagues had previously identified a gene in mice called Ipr1 (intracellular pathogen resistance 1) that plays a significant role in limiting the multiplication of intracellular pathogens M. tuberculosis and Listeria monocytogenes inside host cells.

The Hill team then examined the closest homolog of the mouse gene Ipr1 that can be found in humans--a gene called SP110. Three variations of the SP110 gene were found to be associated with tuberculosis in humans.

The variations of SP110 emerged from an analysis of 20 pieces of genetic material called SNPs that were culled from an original set of 27 SNPs taken from samples provided by 219 families in The Gambia. Two of the variations and their association with tuberculosis were further replicated in samples from 99 families in the Republic of Guinea and 102 families in Guinea-Bissau.

This study was supported by funds from the European Commission, Wellcome Trust, National Institutes of Health, and Medical Research Council.


Story Source:

The above story is based on materials provided by Harvard School of Public Health. Note: Materials may be edited for content and length.


Cite This Page:

Harvard School of Public Health. "Three Human Gene Variants Appear To Influence Tuberculosis Susceptibility." ScienceDaily. ScienceDaily, 22 June 2006. <www.sciencedaily.com/releases/2006/06/060622172843.htm>.
Harvard School of Public Health. (2006, June 22). Three Human Gene Variants Appear To Influence Tuberculosis Susceptibility. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2006/06/060622172843.htm
Harvard School of Public Health. "Three Human Gene Variants Appear To Influence Tuberculosis Susceptibility." ScienceDaily. www.sciencedaily.com/releases/2006/06/060622172843.htm (accessed November 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Ebola Crisis Affecting US Adoptions

Ebola Crisis Affecting US Adoptions

AP (Nov. 20, 2014) The Sanborn family had hoped they'd be able to bring home their 5-year-old adopted son from Liberia by now. But Ebola has forced them to wait. The boy is just one of thousands of orphans in West Africa who've been impacted by the deadly virus. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins