Featured Research

from universities, journals, and other organizations

Genetic Research Reinforces Theory Of Evolution

Date:
August 2, 2006
Source:
Children's Hospital of Pittsburgh
Summary:
Scientists led by a Children's Hospital of Pittsburgh geneticist have found new evidence that a category of genes known as pseudogenes serve no function, an important finding that bolsters the theory of evolution.

Scientists led by a Children’s Hospital of Pittsburgh geneticist have found new evidence that a category of genes known as pseudogenes serve no function, an important finding that bolsters the theory of evolution.

There are approximately 20,000 pseudogenes in the human and other mammalian genomes. In recent years, there has been growing discussion about the nature of these pseudogenes. The issue centers on whether pseudogenes are functional or merely evolutionary relics with no function. It was long believed by geneticists that they were relics, until basic science research published in 2003 found a mouse pseudogene located within the Makorin family of genes that did have a function, namely to cause polycystic kidney disease and a bone disease known as osteogenesis imperfecta.

This finding, discovered in a mouse model, was hailed by proponents of “Intelligent Design” (ID). According to the Intelligent Design Network, the premise of intelligent design holds that certain features of the universe and of living things are best explained by an intelligent cause rather than an undirected process such as natural selection. ID is thus a disagreement with the core scientific basis of evolutionary theory.

However, researchers at Children’s and the Wadsworth Center in New York, including first author Todd A. Gray, PhD, have found scientific evidence that contradicts this finding. The pseudogene in question – Mkrn1-p1 – indeed is not the cause of those diseases, according to senior author Robert D. Nicholls, DPhil, director of the Birth Defects Laboratories at Children’s. Instead, according to Dr. Nicholls, it merely is an inactive copy of a gene, an evolutionary relic as previously believed.

Results of this study are published in the Aug. 8 print issue of the Proceedings of the National Academy of Sciences.

“Discussion over evolution and Intelligent Design really has centered on whether pseudogenes, sometimes called ‘junk DNA,’ have a function or not. The suggestion is that an Intelligent Designer would not make junk DNA, so if a pseudogene does have a function, this is claimed to support the idea of an Intelligent Designer,” Dr. Nicholls said. “But there is no evidence that any of the 20,000 pseudogenes are functional. Our research proves this Makorin pseudogene does not have a function. It has continued to mutate over its short life of a few million years, a fact that supports evolution, and eventually will be discarded from the mouse genome.”

But the most important implication of this research from a patient perspective is that scientists now must go back to the beginning in terms of discovering the genetic mechanism that causes polycystic kidney disease and osteogenesis imperfecta in the mouse model, according to Dr. Nicholls.


Story Source:

The above story is based on materials provided by Children's Hospital of Pittsburgh. Note: Materials may be edited for content and length.


Cite This Page:

Children's Hospital of Pittsburgh. "Genetic Research Reinforces Theory Of Evolution." ScienceDaily. ScienceDaily, 2 August 2006. <www.sciencedaily.com/releases/2006/08/060801230141.htm>.
Children's Hospital of Pittsburgh. (2006, August 2). Genetic Research Reinforces Theory Of Evolution. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2006/08/060801230141.htm
Children's Hospital of Pittsburgh. "Genetic Research Reinforces Theory Of Evolution." ScienceDaily. www.sciencedaily.com/releases/2006/08/060801230141.htm (accessed July 23, 2014).

Share This




More Plants & Animals News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins