Featured Research

from universities, journals, and other organizations

A New Approach To Rheumatoid Arthritis

Date:
September 5, 2006
Source:
Public Library of Science
Summary:
Rheumatoid arthritis drugs work better, at least in arthritic rats, when delivered into the central nervous system, Gary Firestein and colleagues (University of California San Diego) now report in the international open-access medical journal PLoS Medicine.

Rheumatoid arthritis drugs work better, at least in arthritic rats, when delivered into the central nervous system, Gary Firestein and colleagues (University of California San Diego) now report in the international open-access medical journal PLoS Medicine.

Rheumatoid arthritis (RA) is a disease marked by chronic inflammation, leading to joint pain and destruction. Pain and inflammation in the joints are constantly monitored by the central nervous system (CNS, i.e. the brain and spinal cord). Scientists have long suspected that the CNS can regulate inflammation and immune responses in the body's "periphery", but little is known about how this works. Firestein and colleagues focused on a protein called p38, which is involved in a number of cellular processes critical to the development of RA. Several substances that block the action of p38 are effective in animal models of arthritis and are currently being tested in clinical trials in patients with RA.

Based on the observation by other scientists that p38 is activated in the CNS in response to peripheral pain, and on Firestein and colleagues' own finding that this is true in response to inflammation as well, the researchers blocked p38 with drugs directly delivered to the spinal cord of the arthritic rats. They found that the treated rats had substantially less inflammation, arthritis, and joint destruction, compared with rats that had undergone the same treatment but received no active drug. Treatment of arthritic rats with the same amount of drugs given directly under the skin (the "systemic treatment" that is currently being tested in RA patients, but with much higher doses) did not have any beneficial effect on the joints.

These findings suggest that spinal cord administration might reduce the side effects (and possibly the costs) of p38 inhibitors without compromising the benefits to patients. And if future studies confirm that the action of these drugs on the CNS is essential to achieve a response even when administered as a systemic treatment, designing drugs that get into the CNS easier might improve the effectiveness and/or make it possible to use lower doses systemically.

Citation: Boyle DL, Jones TL, Hammaker D, Svensson CI, Rosengren S, et al. (2006) Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. PLoS Med 3(9): e338. DOI: 10.1371/journal.pmed.0030338. (http://dx.doi.org/10.1371/journal.pmed.0030338)


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "A New Approach To Rheumatoid Arthritis." ScienceDaily. ScienceDaily, 5 September 2006. <www.sciencedaily.com/releases/2006/09/060904220336.htm>.
Public Library of Science. (2006, September 5). A New Approach To Rheumatoid Arthritis. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2006/09/060904220336.htm
Public Library of Science. "A New Approach To Rheumatoid Arthritis." ScienceDaily. www.sciencedaily.com/releases/2006/09/060904220336.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins