Featured Research

from universities, journals, and other organizations

Mayo Clinic Finds What Causes Men Pain In Prostate Biopsy And Best Method To Alleviate It

Date:
September 15, 2006
Source:
Mayo Clinic
Summary:
Researchers at Mayo Clinic have evaluated the major sources of pain for some men during in-office prostate biopsy and an anesthetic method that can best lessen it. Findings were presented recently at the annual meeting of the North Central Section of the American Urological Association in San Diego. Most prostate biopsies are performed on men who have abnormal digital rectal exams or abnormally elevated prostate-specific antigen (PSA) tests to evaluate the potential presence of cancer.

Researchers at Mayo Clinic have evaluated the major sources of pain for some men during in-office prostate biopsy and an anesthetic method that can best lessen it. Findings were presented recently at the annual meeting of the North Central Section of the American Urological Association in San Diego.

Related Articles


Most prostate biopsies are performed on men who have abnormal digital rectal exams or abnormally elevated prostate-specific antigen (PSA) tests to evaluate the potential presence of cancer.

"Prostate biopsy evokes significant anxiety for some men due to anticipated pain associated with the procedure," says Richard Ashley, M.D., Mayo Clinic urology resident and lead study investigator. "We also noted that it seemed more men had pain with their prostate biopsies than we would have liked, and we wanted to make this procedure as comfortable as possible."

The researchers found about 16 percent of men who undergo prostate biopsy experienced a moderate or higher level of pain -- pain scores of 5 or more on a scale from 1 to 10. The injection of lidocaine to dull pain during the biopsy caused more pain than the insertion of the transrectal ultrasound probe, a small probe about the size of a cigar inserted into the rectum to produce images of the prostate gland during the biopsy. They also discovered that taking tissue samples in certain locations tested in a prostate biopsy were more likely to cause pain. Specifically, biopsy of the part of the prostate closest to the urethra, the prostate apex, was more painful than biopsy of the part closest to the bladder, the prostate base.

"We found we cannot predict who will have higher levels of pain at the time of a prostate biopsy simply based on the patient's history and features," says Dr. Ashley. "We discovered the location of biopsy was the most predictive of higher pain scores -- not age, body mass index, family history, presence of cancer, inflammation, whether a lump was palpable, or whether the prostate was large or small."

The investigators also found that anesthesia administered by direct infiltration of the prostate apex and the surrounding rectal tissues may provide better pain control during a prostate biopsy than other anesthetic methods.

"The prostate biopsy likely will never be a completely painless procedure, but it should be tolerable," says Dr. Ashley. "Patients should request that anesthetic be used at the time of a biopsy, and pain control should be the standard of care in a urologist's office. It does not take much time, and patients do benefit from this simple procedure to make the biopsy more tolerable. Patients should also be aware that different prostate locations biopsied are associated with more pain, and this may never be completely overcome by anesthetic. However, a complete and thorough sampling of the prostate gland is necessary to give the most accurate diagnosis to the patient."

In the study, Dr. Ashley and colleagues recruited 243 men scheduled to undergo in-office prostate biopsy in the Department of Urology at Mayo Clinic. The researchers randomly assigned the men to three different types of anesthetic: injection between the prostate base and seminal vesicle where the neurovascular bundle lies; intraprostatic injection into the substance of the gland, from the base to the apex; and injection at the prostate apex and surrounding rectal wall tissue. The biopsies were performed using a side-fire ultrasound probe and a biopsy gun. Six biopsies were performed on the right and left side of the prostate of each patient, focusing on the peripheral zone where most cancers occur.

The findings in this study need to be verified by other researchers in a larger study, according to Dr. Ashley.

Other study investigators include: Jonathan Routh, M.D.; Amy Krambeck, M.D.; Sameer Siddiqui, M.D.; Jeffrey Slezak; Lance Mynderse, M.D.; Michael Blute, M.D.; and Matthew Gettman, M.D.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Finds What Causes Men Pain In Prostate Biopsy And Best Method To Alleviate It." ScienceDaily. ScienceDaily, 15 September 2006. <www.sciencedaily.com/releases/2006/09/060915104043.htm>.
Mayo Clinic. (2006, September 15). Mayo Clinic Finds What Causes Men Pain In Prostate Biopsy And Best Method To Alleviate It. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2006/09/060915104043.htm
Mayo Clinic. "Mayo Clinic Finds What Causes Men Pain In Prostate Biopsy And Best Method To Alleviate It." ScienceDaily. www.sciencedaily.com/releases/2006/09/060915104043.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins