Featured Research

from universities, journals, and other organizations

Penn Researchers Find Psoriasis Patients At Increased Risk For Heart Attack

Date:
October 13, 2006
Source:
University of Pennsylvania School of Medicine
Summary:
Psoriasis is an independent risk factor for myocardial infarction, and this risk is greatest in young patients with severe psoriasis, according to Joel M. Gelfand, M.D., M.S.C.E., assistant professor of dermatology, University of Pennsylvania School of Medicine, and lead author of the study that appears in the Oct. 11 issue of JAMA.

Psoriasis is an independent risk factor for myocardial infarction (MI; heart attack), and this risk is greatest in young patients with severe psoriasis, according to Joel M. Gelfand, MD, MSCE, Assistant Professor of Dermatology, University of Pennsylvania School of Medicine, and lead author of the study that appears in the October 11 issue of The Journal of the American Medical Association (JAMA).

Related Articles


Psoriasis is a common, chronic immune-mediated disease that affects about 2% to 3% of the population. The disease is associated with markers of systemic inflammation, and the immunological abnormalities that lead to the development of psoriasis suggest that these patients may be at increased risk for other diseases associated with an inflammatory state.

"Several hospital-based studies have indicated that psoriasis is associated with a higher prevalence of cardiovascular diseases, including MI," said Gelfand. "However, these studies did not control for any associated risk factors for MI."

Gelfand and colleagues conducted a perspective population-based cohort study to determine the risk of heart attack in patients with psoriasis when controlling for major cardiovascular risk factors. The study data was collected from 1988-2002 by more than 500 general practitioners in the United Kingdom who were unaware of the hypothesis being tested.

The data was collected as part of the patient's electronic medial record and maintained in the General Practice Research Database.

The study population consisted of psoriasis patients aged 20-90. Among these patients, 127,139 were defined as having mild psoriasis and 3,831 patients were defined as having severe psoriasis. Adjustments were made for hypertension, diabetes, history of heart attack, hyperlipidemia (an excess of fats or lipids in the blood), age, sex, smoking, and body mass index. Each patient was matched to up to five control subjects who did not have psoriasis. These 556,995 control subjects were seen in the same practice during similar time periods.

The study revealed that the incidence of heart attack was higher in patients with severe psoriasis (5.13 MIs per 1,000 person-years) and mild psoriasis (4.04 MIs per 1,000 person-years) compared with control patients (3.58 MIs per 1,000 person-years). Younger patients with severe psoriasis had the highest relative risk of heart attack. For example, a 40-year-old patient with mild psoriasis had a 20 percent greater risk of having a heart attack than a patient without psoriasis; a 40-year-old patient with severe psoriasis had more than double the risk. A 60-year-old patient with severe psoriasis had a 36 percent increased risk for heart attack. The authors write that the magnitude of association between severe psoriasis and MI in those less than 50 years of age is similar to the magnitude of association for other major cardiac risk factors.

"Our findings are novel and therefore it is important that additional studies be performed to confirm these results and determine their therapeutic implications," write the authors. They recommend that in the meantime, as part of good medical care, patients with psoriasis should be encouraged to aggressively address their modifiable cardiovascular risk factors.

This study was supported by a grant from the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases and an unrestricted grant to the Trustees of the University of Pennsylvania from Biogen Idec.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

University of Pennsylvania School of Medicine. "Penn Researchers Find Psoriasis Patients At Increased Risk For Heart Attack." ScienceDaily. ScienceDaily, 13 October 2006. <www.sciencedaily.com/releases/2006/10/061012190013.htm>.
University of Pennsylvania School of Medicine. (2006, October 13). Penn Researchers Find Psoriasis Patients At Increased Risk For Heart Attack. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2006/10/061012190013.htm
University of Pennsylvania School of Medicine. "Penn Researchers Find Psoriasis Patients At Increased Risk For Heart Attack." ScienceDaily. www.sciencedaily.com/releases/2006/10/061012190013.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins