Featured Research

from universities, journals, and other organizations

Researchers Map Spread Of Pathogens In The Human Body

Date:
October 20, 2006
Source:
University of Cambridge
Summary:
Researchers at the University of Cambridge have discovered a new, more accurate, method of mapping how bacteria spread within the body, a breakthrough that could lead to more effective treatments and prevention of certain bacterial infections.

A cell infected by salmonella.
Credit: Mark Sheppard

Researchers at the University of Cambridge have discovered a new, more accurate, method of mapping how bacteria spread within the body, a breakthrough that could lead to more effective treatments and prevention of certain bacterial infections.

Related Articles


Dr. Pietro Mastroeni, Professor Duncan Maskell at the Centre for Veterinary Science, and their teams have pioneered the integration of mathematical models with observational data to predict the spread of individual bacteria within the human body. Their findings are reported in the November issue of PLoS Biology.

The work analyses the spread and distribution of Salmonella in the body, which is a bacterium that causes typhoid fever and food borne gastroenteritis in humans and animals, with severe medical and veterinary consequences and threats for the food industry. The work is of broad significance as these novel research approaches are applicable to a multitude of pathogenic microorganisms.

These studies indicate that individual bacteria and their progenies cleverly escape from host cells and distribute to new sites of the body, continuously staying one step ahead of the immune response. The type of spread varies between different bacteria, thus posing challenges for the rational treatment or prevention of these infections.

Some antibiotics and vaccines are better at killing bacteria outside of the cells; others are more effective at killing infections within the cells. By understanding where bacterial pathogens hide in the body and how they spread through the body's tissues, doctors will be able to decide the most effective antibiotics or vaccines to treat and prevent various types of infection.

Dr. Mastroeni said, "The fight against bacterial infections is analogous to fighting a battle, if you know where your enemy is and how it moves around, you can make calculated, strategic strikes."

Currently, the debate over the usefulness of multiple-drug therapy must take into account the full evaluation of potential synergistic effects of combining drugs that can target bacteria in different body compartments. Furthermore, drug resistance can be caused, in part, by improper "blanket" use of antibiotics. As Dr. Mastroeni's more precise predictions will lead to the refined use of antibiotics, it will enable the medical field to devise more targeted treatments and to more effectively manage antibiotic drug resistance.

In the past, similar investigations have been hampered by the difficulty of identifying and observing directly the infection process within live tissues. For this study, the Cambridge researchers used advanced fluorescence microscopy techniques to observe intracellular growth of Salmonella bacteria within living cells.


Story Source:

The above story is based on materials provided by University of Cambridge. Note: Materials may be edited for content and length.


Cite This Page:

University of Cambridge. "Researchers Map Spread Of Pathogens In The Human Body." ScienceDaily. ScienceDaily, 20 October 2006. <www.sciencedaily.com/releases/2006/10/061019192435.htm>.
University of Cambridge. (2006, October 20). Researchers Map Spread Of Pathogens In The Human Body. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2006/10/061019192435.htm
University of Cambridge. "Researchers Map Spread Of Pathogens In The Human Body." ScienceDaily. www.sciencedaily.com/releases/2006/10/061019192435.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bionic Ants Could Be Tomorrow's Factory Workers

Bionic Ants Could Be Tomorrow's Factory Workers

Reuters - Innovations Video Online (Mar. 30, 2015) — Industrious 3D printed bionic ants working together could toil in the factories of the future, says German technology company Festo. The robotic insects cooperate and coordinate their actions and movements to achieve a common aim. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com
Captive-Born Panda Triplets Are Eight Months Old

Captive-Born Panda Triplets Are Eight Months Old

Reuters - Light News Video Online (Mar. 30, 2015) — The world&apos;s only surviving captivity-born panda triplets turn eight months old, according to China’s state media. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Lions Make Surprise Comeback in Gabon

Lions Make Surprise Comeback in Gabon

AFP (Mar. 30, 2015) — Lions have made a comeback in southeast Gabon, after disappearing for years, according to live footage from US wildlife organisation Panthera. Duration: 00:32 Video provided by AFP
Powered by NewsLook.com
Ancient Egyptian Beer Making Vessels Discovered in Israel

Ancient Egyptian Beer Making Vessels Discovered in Israel

AFP (Mar. 30, 2015) — Fragments of pottery used by Egyptians to make beer and dating back 5,000 years have been discovered on a building site in Tel Aviv, the Israeli Antiquities Authority said on Sunday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins