Featured Research

from universities, journals, and other organizations

Researchers Study Effects Of Aricept In Pediatric Brain Cancer Survivors

Date:
November 5, 2006
Source:
Wake Forest University Baptist Medical Center
Summary:
A pediatric oncologist at Brenner Children's Hospital is evaluating whether a drug typically used to treat Alzheimer's patients will help brain cancer survivors avoid the learning and memory problems that are common after radiation therapy.

A pediatric oncologist at Brenner Children's Hospital is evaluating whether a drug typically used to treat Alzheimer's patients will help brain cancer survivors avoid the learning and memory problems that are common after radiation therapy.

Related Articles


The drug, called AriceptTM, will be given daily for six months to brain cancer survivors who have received cranial radiation. Sharon Castellino, M.D., will follow these patients for six months to see if the drug can help prevent a decline in their cognitive abilities.

The Comprehensive Cancer Center at Wake Forest Baptist completed a successful pilot study using this drug in adults last year. The researchers decided to try the drug after observing that radiation-induced brain injury resembles Alzheimer's disease and other forms of dementia not only in the clinical symptoms but also in what is seen with brain imaging,

"We know that pediatric brain cancer patients are at risk for developing cognitive problems later in life," said Castellino. "They may have memory problems, low school performance, declines in IQ, behavioral problems, and these problems may lead to poor quality of life. Patients who receive cranial radiation as part of their treatment regime are at greater risk for developing these problems. We are hoping this therapy will enable them to maintain their baseline cognitive abilities and social relationships at school and at home."

Castellino and colleagues will enroll 35 patients, ages 8 to 17 years, in this study over the next two years. Patients will be asked to take a series of neuropsychological tests to establish a baseline of their cognitive abilities before starting treatment. Patients must have completed all therapy at least one year ago.

Brenner Children's Hospital treats about 20 pediatric patients with brain tumors each year. Over two-third of patients who are diagnosed with a malignant brain tumor will receive cranial radiation, she said.

"Cranial radiation can be particularly damaging to the brain if the treatment area is large," Castellino said. "The age of the child also plays a significant role in developing cognitive problems. Radiation therapy can stunt the normal development of a child's brain."

The $100,000 study was funded by the Lance Armstrong Foundation, which seeks to inspire and empower people affected by cancer. Brenner Children's Hospital is part of Wake Forest University Baptist Medical Center.


Story Source:

The above story is based on materials provided by Wake Forest University Baptist Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Wake Forest University Baptist Medical Center. "Researchers Study Effects Of Aricept In Pediatric Brain Cancer Survivors." ScienceDaily. ScienceDaily, 5 November 2006. <www.sciencedaily.com/releases/2006/11/061103103948.htm>.
Wake Forest University Baptist Medical Center. (2006, November 5). Researchers Study Effects Of Aricept In Pediatric Brain Cancer Survivors. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2006/11/061103103948.htm
Wake Forest University Baptist Medical Center. "Researchers Study Effects Of Aricept In Pediatric Brain Cancer Survivors." ScienceDaily. www.sciencedaily.com/releases/2006/11/061103103948.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins