Featured Research

from universities, journals, and other organizations

Hormone Linked To Brain's Cravings For Food And Other Energy Sources

Date:
November 14, 2006
Source:
Yale University
Summary:
Ghrelin, a hormone produced in the stomach, induces food intake and operates through a brain region that controls cravings for food and other energy sources, researchers at Yale School of Medicine report in the October 19 online issue of the Journal of Clinical Investigation.

Ghrelin, a hormone produced in the stomach, induces food intake and operates through a brain region that controls cravings for food and other energy sources, researchers at Yale School of Medicine report in the October 19 online issue of The Journal of Clinical Investigation.

Related Articles


Ghrelin was previously associated with growth hormone release, appetite, learning, and memory and has now been linked with the reward circuitry of the brain that regulates food cravings.

According to lead author Tamas Horvath, components of the reward circuitry of the ventral tegmental area (VTA), may be responsible for overeating and addiction. "Targeting this region pharmacologically is an interesting tool to explore," said Horvath, chair of the Section of Comparative Medicine at Yale School of Medicine and professor of comparative medicine, neurobiology and obstetrics, gynecology & reproductive sciences.

In this study, Horvath and colleagues found that ghrelin could signal directly in the VTA region and activate dopamine neuronal activity, which controls reward-associated behavior to promote interest in food as a reward. As a default, ghrelin's action may also alter seeking of drugs and substances that work through the same pathways.

"We found that if we selectively block ghrelin in this part of the brain, we can suppress feeding or the need to seek out food and energy," said Horvath. "It also suggests that perhaps it could interfere with the need to seek out drugs as well."

Horvath said ghrelin, which was originally found to signal in the hypothalamus, has now been shown to have a broad influence on various brain functions. "This makes sense because the major driving force of life is seeking energy to survive," he said. "Future studies will explore the relationships between ghrelin and cocaine addiction."

The National Institute of Diabetes and Digestive and Kidney Disease of the National Institutes of Health funded the study.

Other authors on the study include first author Alfonso Abizaid, Zhong-Wu Liu, Zane B. Andrews, Marya Shanabrough, Erzsebet Borok, John Elsworth, Robert Roth, Mark Sleeman, Marina Picciotto, Matthias Tschop, and Xiao-Bing Gao.

Citation: Journal of Clinical Investigation, 116, 12 (Online: October 19; Print: December 2006)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Hormone Linked To Brain's Cravings For Food And Other Energy Sources." ScienceDaily. ScienceDaily, 14 November 2006. <www.sciencedaily.com/releases/2006/11/061113170826.htm>.
Yale University. (2006, November 14). Hormone Linked To Brain's Cravings For Food And Other Energy Sources. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2006/11/061113170826.htm
Yale University. "Hormone Linked To Brain's Cravings For Food And Other Energy Sources." ScienceDaily. www.sciencedaily.com/releases/2006/11/061113170826.htm (accessed October 30, 2014).

Share This



More Mind & Brain News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Techy Tots Are Forefront of London's Baby Show

Techy Tots Are Forefront of London's Baby Show

AP (Oct. 28, 2014) Moms and Dads get a more hands-on approach to parenting with tech-centric products for raising their little ones. (Oct. 28) Video provided by AP
Powered by NewsLook.com
Cocoa Could Be As Good For Memory As It Is For A Sweet Tooth

Cocoa Could Be As Good For Memory As It Is For A Sweet Tooth

Newsy (Oct. 27, 2014) Researchers have come up with another reason why dark chocolate is good for your health. A substance in the treat can reportedly help with memory. Video provided by Newsy
Powered by NewsLook.com
Five-Year-Olds Learn Coding as Britain Eyes Digital Future

Five-Year-Olds Learn Coding as Britain Eyes Digital Future

AFP (Oct. 27, 2014) Coding has become compulsory for children as young as five in schools across the UK. Making it the first major world economy to overhaul its IT teaching and put programming at its core. Duration: 02:19 Video provided by AFP
Powered by NewsLook.com
Academic Scandal Shocks UNC

Academic Scandal Shocks UNC

AP (Oct. 23, 2014) A scandal involving bogus classes and inflated grades at the University of North Carolina was bigger than previously reported, a new investigation found. (Oct. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins