Featured Research

from universities, journals, and other organizations

Obese Kidney Transplant Patients Twice As Likely To Die In The First Year Or Suffer Organ Failure

Date:
December 26, 2006
Source:
Blackwell Publishing Ltd.
Summary:
Six percent of obese kidney transplant patients die in the first year and 14 percent suffer transplant failures. The figures for non obese patients are three percent and eight percent. Experts from seven university hospitals in the Netherlands studied 2067 patients. Their finding appear in the November issue of Transplant International.

Survival and successful kidney transplant rates are significantly lower when people are obese, according to a study of over 2,000 patients published in the November issue of Transplant International.

A team of experts from across the Netherlands studied the medical profiles of 4,245 adults who had received kidney transplants, using data from the Netherlands Organ Transplantation Registry.

In 2067 cases there was sufficient information to calculate their Body Mass Index (BMI) -- based on their weight and height - at the time of their kidney transplant.

They discovered that six per cent of patients with a BMI of more than 30 died in the first year after transplant, compared with three per cent of patients with a BMI of less than 30.

By year five, the difference was even greater, with an 81 per cent survival rate for the obese patients and an 89 per cent survival rate for patients who were not obese.

The same pattern emerged when they looked at the success of the transplant itself.

A year after the transplant was carried out, 14 per cent of obese patients had experienced a transplant failure, compared with eight per cent of non obese patients.

After five years, 71 per cent of obese patients still had a successfully transplanted kidney, compared with 80 per cent of the patients with a lower BMI.

Obese patients were more likely suffer transplant failure through infection or permanent non-functioning, but the numbers for obese and non-obese patients were both fairly low.

There were no significant differences between the two groups when it came to why patients died, but there was a trend for obese patients to suffer more infections and fatal heart conditions.

Obese patients in the study group also tended to be older and were more likely to be female

"The prevalence of obesity in patients with end-stage renal disease is increasingly rapidly" says lead researcher Dr Jeroen Aalten from the Department of Nephrology at the University Medical Center in Nijmegen.

"It's estimated that 60 per cent of renal transplant candidates in the United States and 10 per cent in the Netherlands are obese or overweight.

"These figures have been rising consistently in recent years. This could be due to a general rise in obesity worldwide, but we can't rule out that it may have been affected by changes in inclusion criteria for kidney transplants."

The study -- which was carried out by Nephrology specialists from seven university hospitals across the Netherlands -- concluded that there is a significant relationship between obesity and increased transplant failure or death.

The authors acknowledge that there has been considerable debate about whether obese patients are suitable transplant candidates.

But they also point out that while obesity is preventable and fundamentally curable, compared to age and diabetes, experience shows that it can be very difficult for people with end-stage renal disease to lose weight.

"Our conclusion is that it's not fair to deny obese patients the chance of a kidney transplant as they still do better after a transplant than on dialysis" says Dr Aalten.

"However we shouldn't disregard the increased risk for obese patients after transplantation and we also need to bear in mind that it is important to give scarce resources to patients with the lowest risk.

"It is very important that patients facing kidney transplant are fully informed about the risks that they face and are encouraged to lose weight wherever possible."


Story Source:

The above story is based on materials provided by Blackwell Publishing Ltd.. Note: Materials may be edited for content and length.


Cite This Page:

Blackwell Publishing Ltd.. "Obese Kidney Transplant Patients Twice As Likely To Die In The First Year Or Suffer Organ Failure." ScienceDaily. ScienceDaily, 26 December 2006. <www.sciencedaily.com/releases/2006/11/061113180116.htm>.
Blackwell Publishing Ltd.. (2006, December 26). Obese Kidney Transplant Patients Twice As Likely To Die In The First Year Or Suffer Organ Failure. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2006/11/061113180116.htm
Blackwell Publishing Ltd.. "Obese Kidney Transplant Patients Twice As Likely To Die In The First Year Or Suffer Organ Failure." ScienceDaily. www.sciencedaily.com/releases/2006/11/061113180116.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins