Featured Research

from universities, journals, and other organizations

Link Between Rheumatoid Arthritis And Cancer

Date:
March 12, 2007
Source:
John Wiley & Sons, Inc.
Summary:
Inflammatory arthritis may increase the risk of dying from cancer but not developing it, suggests long-term community-based study.

Inflammatory arthritis may increase the risk of dying from cancer but not developing it, suggests long-term community-based study.

Related Articles


Patients with rheumatoid arthritis (RA), a chronic inflammatory autoimmune disease, have a high risk of death from disease -- at least double the risk of the general population, studies overwhelmingly show. Evidence has been less clear on whether RA patients are exceptionally vulnerable to dying from cancer.

The first study to investigate whether patients with RA who develop cancer have a decreased rate of survival, featured in the March 2007 issue of Arthritis & Rheumatism, also examined the impact of rheumatic disease on overall cancer incidence. Conducted by a team of researchers in the United Kingdom, it focused on 2,105 patients with recent onset inflammatory polyarthritis (IP). Over time, a large proportion of new-onset IP cases evolve into RA, meeting the diagnostic criteria of the American College of Rheumatology.

Researchers followed the IP patients over a 10-year period to detect the occurrence of cancer. Among the group, they identified 123 cases of cancer for analysis. These cases included bone, lung, breast, prostate, urinary, colon, and brain cancers; cancers of the digestive, respiratory, and central nervous systems; cancers of the blood cells and cancerous tumors; but excluding non-melanotic skin cancers. Then, they compared these rates with the rates of cancer in the general population from the same geographic area, Norfolk, adjusting for difference in age and sex.

Overall, the incidence of cancer was not increased in the IP subjects compared with the general population. However, the risk of blood cell cancers was increased among the IP sample, a finding researchers expected given the association between RA and lymphoma.

The study also compared the number of deaths in patients with cancer and inflammatory arthritis with that of cancer patients without a history of inflammatory arthritis. The finding was striking: a 40 percent increase in mortality in patients who suffered both IP, or RA, and cancer.

"The results of this study demonstrated that 5-year cancer survival in patients with IP is substantially reduced in comparison with that in the general population, even after adjusting for differences in age, sex, and cancer site, whereas the overall cancer incidence does not seem to be increased," observes Alan Silman, M.D., an epidemiologist with the University of Manchester and the study's leading researcher. Whether targeted cancer therapies could improve the survival rate for RA patients remains a subject for further research.

Article: "Influence of Inflammatory Polyarthritis on Cancer Incidence and Survival: Results from a Community-Based Prospective Study," Jarrod Franklin, Mark Lunt, Diane Bunn, Deborah Symmons, and Alan Silman, Arthritis & Rheumatism, March 2007, (DOI: 10.1002/art.22430).


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Link Between Rheumatoid Arthritis And Cancer." ScienceDaily. ScienceDaily, 12 March 2007. <www.sciencedaily.com/releases/2007/02/070227105344.htm>.
John Wiley & Sons, Inc.. (2007, March 12). Link Between Rheumatoid Arthritis And Cancer. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2007/02/070227105344.htm
John Wiley & Sons, Inc.. "Link Between Rheumatoid Arthritis And Cancer." ScienceDaily. www.sciencedaily.com/releases/2007/02/070227105344.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins