Featured Research

from universities, journals, and other organizations

New Project To Analyze Why Polycystic Ovary Syndrome And Insulin Resistance Are So Closely Linked

Date:
March 14, 2007
Source:
Imperial College London
Summary:
Understanding the link between Polycystic Ovary Syndrome (PCOS) and insulin resistance is the aim of a new project announced today. It is known that women with PCOS have a 3-fold increase in their risk of developing type-2 diabetes, where the body does not produce enough insulin or cannot use insulin properly. Insulin resistance is an important factor in the condition, which is the most common female hormone disorder.

Understanding the link between Polycystic Ovary Syndrome (PCOS) and insulin resistance is the aim of a new project announced today, funded by the charity WellBeing of Women.

It is known that women with PCOS have a 3-fold increase in their risk of developing type-2 diabetes, where the body does not produce enough insulin or cannot use insulin properly. Insulin resistance is an important factor in the condition, which is the most common female hormone disorder. PCOS affects between 5 and 10 per cent of women and is a major cause of infertility.

The new 97K project aims to identify a defective point on the insulin signalling pathway in women with PCOS. The researchers, from Imperial College London, hope this will enable the development of new therapies which target this part of the pathway, to counter the insulin resistance and the fertility problems that PCOS can cause.

Insulin is released from cells in the pancreas after eating and it signals insulin-sensitive tissues (such as fat and muscle) to take up glucose, keeping glucose levels in the bloodstream normal. In people with insulin resistance, normal amounts of insulin are not adequate to produce a normal glucose response, meaning that levels of insulin in the bloodstream need to be higher to achieve normal blood sugar levels.

Insulin resistance (and/or the compensatory excess of insulin in the bloodstream), may contribute to abnormalities in function of the ovaries that lead to many of the symptoms of PCOS. These include irregular periods, or no periods at all; fertility problems; weight gain; acne; and excessive hair growth (hirsutism).

A longer term concern is that insulin resistance also predisposes people to diabetes. In some patients the pancreas is unable, in the long-term, to produce enough insulin to compensate for the resistance of the tissues to insulin action. Consequently, blood sugar levels rise. What is not known is why PCOS and insulin resistance are so closely related.

The researchers hope that the new project will explain the link between PCOS and insulin resistance and how the link manifests itself at the level of individual cells.

The researchers will be looking at how ovarian cells metabolise glucose in women both with and without PCOS.

Professor Stephen Franks said: "PCOS gives rise to a range of symptoms. These may be very distressing not only because of problems with irregular periods and with fertility but also because of excess body hair, acne or alopecia. We still do not fully understand the underlying cause or causes of PCOS but insulin resistance plays an important part in many patients.

"These studies will give us the chance to look directly at the mechanism of insulin resistance at the level of an important target tissue -- the ovary. We expect the results of these studies to give us information that will help to devise new and more effective methods of treatment for this very common hormone problem," he added.



Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "New Project To Analyze Why Polycystic Ovary Syndrome And Insulin Resistance Are So Closely Linked." ScienceDaily. ScienceDaily, 14 March 2007. <www.sciencedaily.com/releases/2007/03/070312111304.htm>.
Imperial College London. (2007, March 14). New Project To Analyze Why Polycystic Ovary Syndrome And Insulin Resistance Are So Closely Linked. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2007/03/070312111304.htm
Imperial College London. "New Project To Analyze Why Polycystic Ovary Syndrome And Insulin Resistance Are So Closely Linked." ScienceDaily. www.sciencedaily.com/releases/2007/03/070312111304.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins