Featured Research

from universities, journals, and other organizations

Brain's 'Default Mode' Awry In Schizophrenia

Date:
March 14, 2007
Source:
Yale University
Summary:
The "default mode," or baseline condition when the brain is idling, is not properly coordinated in patients with schizophrenia and this aberrant activity may be caused by poor connectivity between brain networks, a Yale School of Medicine researcher reports.

Although in normal comparison subjects, the network, as measured by its blood flow with fMRI, resonates slowly and regularly, in schizophrenia the activity is increased and more irregular and also correlates with positive symptoms.
Credit: Image courtesy of Yale University

The “default mode,” or baseline condition when the brain is idling, is not properly coordinated in patients with schizophrenia and this aberrant activity may be caused by poor connectivity between brain networks, a Yale School of Medicine researcher reports.

Related Articles


Co-author Godfrey Pearlson, M.D., professor of psychiatry, said he and his colleagues found that regions of the brain known previously to be individually abnormal in patients with schizophrenia, also function abnormally in concert in the default mode network.

“In addition, the extent of the default mode abnormalities correlated with the severity of auditory hallucinations, delusional thoughts, and attention deficits that are hallmarks of schizophrenia,” Pearlson said.

Although the exact role of the default network is unknown, it is thought to involve response to stimuli as well as self-referential and reflective activity that includes memory retrieval, inner speech, mental images, emotions, and planning of future events.

Schizophrenia is a psychotic disorder that alters patients’ perception, thought processes, and behavior as evidenced by hallucinations, delusions, disorganized speech or behavior, social withdrawal, and varied cognitive deficits. Episodic memory and attention are significantly impaired in schizophrenia.

A central feature of schizophrenia is disturbed integration of activity across multiple brain regions, or dysfunctional connectivity between frontal temporal brain regions. Symptoms of schizophrenia have been attributed to a failure of functional integration or aberrant connectivity among regions or systems of the brain.

The study included 21 patients with schizophrenia and 22 healthy subjects. The group performed a straightforward task while undergoing functional magnetic resonance imaging in which they were asked to detect an infrequent target sound within a series of standard and novel sounds. In the healthy subjects, the default mode network resonated slowly and regularly as observed by blood flow. In the patients with schizophrenia, the activity in the brain increased and was significantly more irregular, although they performed equally well on the task.

Abigail Garrity of Trinity College was the lead author and Vince Calhoun of the Institute of Living/Hartford Hospital was the senior author. Co-authors included Dan Lloyd of Trinity College and Kristen McKiernan and Kent Kiehl of the Institute of Living/Hartford Hospital.

The study was supported by, among other funders, the National Institutes of Health in a MERIT grant to Pearlson.

Reference: American Journal of Psychiatry 164: 450-457 (March 2007)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Brain's 'Default Mode' Awry In Schizophrenia." ScienceDaily. ScienceDaily, 14 March 2007. <www.sciencedaily.com/releases/2007/03/070313172329.htm>.
Yale University. (2007, March 14). Brain's 'Default Mode' Awry In Schizophrenia. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2007/03/070313172329.htm
Yale University. "Brain's 'Default Mode' Awry In Schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2007/03/070313172329.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com
Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Reuters - Innovations Video Online (Mar. 25, 2015) European researchers say our smartphone use offers scientists an ideal testing ground for human brain plasticity. Dr Ako Ghosh&apos;s team discovered that the brains and thumbs of smartphone users interact differently from those who use old-fashioned handsets. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Many Don't Know They Have Alzheimer's, But Their Doctors Do

Many Don't Know They Have Alzheimer's, But Their Doctors Do

Newsy (Mar. 24, 2015) According to a new study by the Alzheimer&apos;s Association, more than half of those who have the degenerative brain disease aren&apos;t told by their doctors. Video provided by Newsy
Powered by NewsLook.com
A Quick 45-Minute Nap Can Improve Your Memory

A Quick 45-Minute Nap Can Improve Your Memory

Newsy (Mar. 23, 2015) Researchers found those who napped for 45 minutes to an hour before being tested on information recalled it five times better than those who didn&apos;t. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins