Featured Research

from universities, journals, and other organizations

Emory To Develop Islet Transplant Technology

Date:
March 26, 2007
Source:
Emory University
Summary:
Using a $2.5 million, three-year grant from the Juvenile Diabetes Research Foundation (JDRF), Emory transplant researchers plan to develop pig islets as an alternative to human islets for transplant into patients with Type 1 diabetes. If their research is successful, clinical trials of the porcine islet transplants into humans could begin within the next three years.

Using a $2.5 million, three-year grant from the Juvenile Diabetes Research Foundation (JDRF), Emory transplant researchers plan to develop pig islets as an alternative to human islets for transplant into patients with Type 1 diabetes. If their research is successful, clinical trials of the porcine islet transplants into humans could begin within the next three years. Christian P. Larsen, MD, DPhil, director of the Emory Transplant Center, is principal investigator of the grant.

Individuals with Type 1 diabetes, which usually develops early in life, are unable to produce their own insulin because their pancreatic islets do not function. In 2000, researchers in Edmonton, Alberta, first reported that islet transplantation can produce a high rate of insulin independence with excellent metabolic control. This was followed over the next several years by a series of clinical trials focused on improving the islet transplant procedure. Emory was the first, and is still the only, center in Georgia thus far to transplant human islets. Emory physician/researchers have performed 16 islet transplants into nine patients since 2003.

Despite some success in helping patients forgo or cut down on insulin injections, the islet transplant procedure still faces significant challenges. Transplant recipients must take toxic immunosuppressant drugs to improve long-term survival of the islets. Emory scientists, based on research begun at the Yerkes National Primate Research Center and continued in human clinical trials, are leaders in a national effort to develop less toxic drugs for islet and solid organ transplants.

At the same time, researchers have realized the vast gap between the number of human islets available from current sources and the millions with Type 1 diabetes who could potentially benefit from safe and effective islet replacement therapy. Xenotransplants, which are transplants between two different species of animals, have been considered as an alternative that could provide much larger quantities of islets for human transplant.

"While support from the JDRF has allowed us to make considerable progress in improving immunosuppressant drugs and in refining the islet transplant procedure, a significant problem remains with the available supply of islets," says Dr. Larsen. "There simply will never be enough islets available for transplant if we must rely on human deceased donor pancreases. We are very optimistic that porcine islets may provide the answer to this difficult challenge."

With the JDRF grant, the Emory scientists will use a nonhuman primate model at the Yerkes Research Center to develop their porcine islet transplant strategy. This will include successfully preparing the porcine islets for transplant; circumventing the potent rejection barriers to acceptance of the xenograft; and understanding and minimizing the risk of transmission of porcine pathogens to human transplant recipients and the general population.


Story Source:

The above story is based on materials provided by Emory University. Note: Materials may be edited for content and length.


Cite This Page:

Emory University. "Emory To Develop Islet Transplant Technology." ScienceDaily. ScienceDaily, 26 March 2007. <www.sciencedaily.com/releases/2007/03/070319175919.htm>.
Emory University. (2007, March 26). Emory To Develop Islet Transplant Technology. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2007/03/070319175919.htm
Emory University. "Emory To Develop Islet Transplant Technology." ScienceDaily. www.sciencedaily.com/releases/2007/03/070319175919.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins