Featured Research

from universities, journals, and other organizations

Sodium Hydration Therapies Equally Effective

Date:
April 3, 2007
Source:
American College of Cardiology
Summary:
In patients undergoing cardiac catheterization, contrast dye injection can sometimes cause contrast-induced nephropathy (CIN), otherwise known as acute renal failure. According to a recent study peri-procedural hydration treatment with either sodium bicarbonate or sodium chloride show similar rates of protection against CIN.

In patients undergoing cardiac catheterization, contrast dye injection can sometimes cause contrast-induced nephropathy (CIN), otherwise known as acute renal failure. According to a study presented at the American College of Cardiology's Innovation in Intervention: i2Summit, peri-procedural hydration treatment with either sodium bicarbonate or sodium chloride show similar rates of protection against CIN.

Related Articles


Patients undergoing coronary angiography to identify obstructions in the arteries are at risk for CIN, a dye-contrast complication that can lead to extended hospital stays, increased costs, dialysis and in some cases, death. Previous studies have evaluated hydration treatment with both sodium chloride and sodium bicarbonate fluids in animal models. With evidence suggesting sodium bicarbonate may be an effective strategy to improve hydration, researchers designed a human trial to compare the efficacy of sodium chloride versus sodium bicarbonate to prevent CIN in patients undergoing cardiac procedures.

The single-center randomized controlled trial at Kaiser Permanente, Los Angeles Medical Center, evaluated 353 patients with at least moderate renal dysfunction and one or more of the following: age of 75 or older, diabetes mellitus, hypertension or congestive heart failure (CHF). Prior to the cardiac catheterization, patients were randomized to hydration with sodium chloride (n=178) or sodium bicarbonate (n=175). Study participants were given either study fluid at the same rate: 3 mL/kg for one hour before, and 1.5 mL/kg during and for four hours after the cardiac catheterization. Ioxilan, a non-iconic, low osmolar contrast agent was administered during all procedures.

The objective of the trial was to see how many patients developed renal dysfunction, defined as a less than 25 percent decrease in the GFR (a measure of kidney function). This result was seen in 13.5 percent of the sodium chloride group vs.13.6 percent of the sodium bicarbonate group. Of the patients evaluated in this comparative trial, there were no differences between the groups in age, gender, BMI, prior MI, prior CHF, percutaneous revascularization at the procedure, diabetes mellitus and NAC pre-treatment. The number of patients with baseline severe kidney dysfunction (eGFR <=30) and the average contrast volume were similar in both treatment groups.

"Kidney dysfunction showed no variable difference between the two groups, revealing that hydration with sodium bicarbonate was not any more effective than sodium chloride in this randomized trial," said Somjot Brar, M.D., of Kaiser Permanente Southern California, and lead study author. "Our team is evaluating other possible therapies as there remains a need to improve methods to prevent CIN in patients undergoing angiography."

Dr. Brar will present results of the "A Randomized Controlled Trial for the Prevention of Contrast Induced Nephropathy with Sodium Bicarbonate vs. Sodium Chloride in Persons Undergoing Coronary Angiography (the MEENA Trial)" study at the American College of Cardiology's Innovation in Intervention: i2Summit.


Story Source:

The above story is based on materials provided by American College of Cardiology. Note: Materials may be edited for content and length.


Cite This Page:

American College of Cardiology. "Sodium Hydration Therapies Equally Effective." ScienceDaily. ScienceDaily, 3 April 2007. <www.sciencedaily.com/releases/2007/03/070326120919.htm>.
American College of Cardiology. (2007, April 3). Sodium Hydration Therapies Equally Effective. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2007/03/070326120919.htm
American College of Cardiology. "Sodium Hydration Therapies Equally Effective." ScienceDaily. www.sciencedaily.com/releases/2007/03/070326120919.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Hikers Rescued After Fall from Oregon Mountain

Hikers Rescued After Fall from Oregon Mountain

AP (Feb. 1, 2015) Two climbers who were hurt in a fall on Mount Hood are now being treated for their injuries. Rescue officials say they were airlifted off the mountain Saturday afternoon by an Oregon National Guard helicopter. (Feb. 2) Video provided by AP
Powered by NewsLook.com
Smart Glasses Augment Reality to Help Visually Impaired

Smart Glasses Augment Reality to Help Visually Impaired

Reuters - Innovations Video Online (Feb. 1, 2015) New augmented reality smart glasses developed by researchers at Oxford University can help people with visual impairments improve their vision by providing depth-based feedback, allowing users to "see" better. Joel Flynn reports. Video provided by Reuters
Powered by NewsLook.com
Flu Season Hitting Elderly Hard

Flu Season Hitting Elderly Hard

Reuters - US Online Video (Jan. 31, 2015) The CDC says this year&apos;s flu season is hitting people 65 years of age and older especially hard. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins