Featured Research

from universities, journals, and other organizations

Alzheimer's Patients Are Dying Early Because Of Controversial Drugs

Date:
March 31, 2007
Source:
Alzheimer's Research Trust
Summary:
Many Alzheimer's patients are dying earlier because of sedatives they are being prescribed, according to new research from the Alzheimer's Research Trust. Results from a five-year project found that the drugs were linked with a significant increase in long-term mortality.

Rebecca Wood, Chief Executive of the Alzheimer's Research Trust.
Credit: Image courtesy of Alzheimer's Research Trust

Many Alzheimer’s patients are dying earlier because of sedatives they are being prescribed, according to new groundbreaking research from the Alzheimer's Research Trust.

Related Articles


Results from a five-year project, funded by the Alzheimer’s Research Trust and presented at the charity’s conference in Edinburgh, found that the drugs were linked with a significant increase in long-term mortality - with patients dying on average six months earlier.

The investigation by King’s College London researchers found that the sedatives, known as neuroleptics, were associated with a significant deterioration in verbal fluency and cognitive function, and that neuroleptic treatment had no benefit to patients with the mildest symptoms.

Significantly, up to 45% of people with Alzheimer’s disease residing in nursing homes are prescribed neuroleptics as a treatment for behavioural symptoms such as aggression.

Professor Clive Ballard, Professor of Age Related Disorders at King’s College London, and lead researcher on the project, said:

“It is very clear that even over a six month period of treatment, there is no benefit of neuroleptics in treating the behaviour in people with Alzheimer’s disease when the symptoms are mild – specifically when a measure of behavioural disturbance known as the Neuropsychiatric Inventory Score is equal to or less than 14. For people with more severe behavioural symptoms, balancing the potential benefits against increased mortality and other adverse events is more difficult, but this study provides an important evidence base to inform this decision-making process.”

Rebecca Wood, Chief Executive of the Alzheimer’s Research Trust, said:

“These results are deeply troubling and highlight the urgent need to develop better treatments. 700,000 people are affected by dementia in the UK, a figure that will double in the next 30 years. The Government needs to make Alzheimer’s research funding a priority.

“Only 11 is spent on UK research into Alzheimer's for every person affected by the disease, compared to 289 for cancer patients.”

Janet Carter, from West Yorkshire, whose parents were both diagnosed with Alzheimer’s, said: “My father died relatively quickly after he was diagnosed with Alzheimer’s and he was prescribed a neuroleptic drug. My mother, who also has Alzheimer’s, is still alive almost a decade after being diagnosed. She was never given these drugs. I don’t know if what happened to my dad is linked to these findings, but either way I’m very shocked by them.”

This is the largest neuroleptic withdrawal study of Alzheimer's patients and the only long-term one of its type.


Story Source:

The above story is based on materials provided by Alzheimer's Research Trust. Note: Materials may be edited for content and length.


Cite This Page:

Alzheimer's Research Trust. "Alzheimer's Patients Are Dying Early Because Of Controversial Drugs." ScienceDaily. ScienceDaily, 31 March 2007. <www.sciencedaily.com/releases/2007/03/070330230946.htm>.
Alzheimer's Research Trust. (2007, March 31). Alzheimer's Patients Are Dying Early Because Of Controversial Drugs. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2007/03/070330230946.htm
Alzheimer's Research Trust. "Alzheimer's Patients Are Dying Early Because Of Controversial Drugs." ScienceDaily. www.sciencedaily.com/releases/2007/03/070330230946.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Humanoid Robot Can Recognise and Interact With People

Humanoid Robot Can Recognise and Interact With People

Reuters - Innovations Video Online (Apr. 20, 2015) An ultra-realistic humanoid robot called &apos;Han&apos; recognises and interprets people&apos;s facial expressions and can even hold simple conversations. Developers Hanson Robotics hope androids like Han could have uses in hospitality and health care industries where face-to-face communication is vital. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Labour Party Warns Britain's Health Service 'on Life Support'

Labour Party Warns Britain's Health Service 'on Life Support'

AFP (Apr. 20, 2015) Britain&apos;s opposition Labour Party Monday claimed the National Health Service (NHS) was &apos;on life support&apos; as it turned its attention to the state-run service, which is a key issue for the UK&apos;s May 7 general election. Video provided by AFP
Powered by NewsLook.com
Sierra Leone Students Back to School After Long Ebola Closure

Sierra Leone Students Back to School After Long Ebola Closure

Reuters - News Video Online (Apr. 20, 2015) After an eight-month break, children in Sierra Leone return to school for the first time since the beginning of the Ebola outbreak. Nathan Frandino reports. Video provided by Reuters
Powered by NewsLook.com
Teen E-Cigarette Use Triples, Government Debates Regulations

Teen E-Cigarette Use Triples, Government Debates Regulations

Newsy (Apr. 19, 2015) The Centers for Disease Control and Prevention says in 2014, 13.4 percent of high school students reported smoking an e-cigarette within 30 days. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins