Featured Research

from universities, journals, and other organizations

Alzheimer's Patients Are Dying Early Because Of Controversial Drugs

Date:
March 31, 2007
Source:
Alzheimer's Research Trust
Summary:
Many Alzheimer's patients are dying earlier because of sedatives they are being prescribed, according to new research from the Alzheimer's Research Trust. Results from a five-year project found that the drugs were linked with a significant increase in long-term mortality.

Rebecca Wood, Chief Executive of the Alzheimer's Research Trust.
Credit: Image courtesy of Alzheimer's Research Trust

Many Alzheimer’s patients are dying earlier because of sedatives they are being prescribed, according to new groundbreaking research from the Alzheimer's Research Trust.

Related Articles


Results from a five-year project, funded by the Alzheimer’s Research Trust and presented at the charity’s conference in Edinburgh, found that the drugs were linked with a significant increase in long-term mortality - with patients dying on average six months earlier.

The investigation by King’s College London researchers found that the sedatives, known as neuroleptics, were associated with a significant deterioration in verbal fluency and cognitive function, and that neuroleptic treatment had no benefit to patients with the mildest symptoms.

Significantly, up to 45% of people with Alzheimer’s disease residing in nursing homes are prescribed neuroleptics as a treatment for behavioural symptoms such as aggression.

Professor Clive Ballard, Professor of Age Related Disorders at King’s College London, and lead researcher on the project, said:

“It is very clear that even over a six month period of treatment, there is no benefit of neuroleptics in treating the behaviour in people with Alzheimer’s disease when the symptoms are mild – specifically when a measure of behavioural disturbance known as the Neuropsychiatric Inventory Score is equal to or less than 14. For people with more severe behavioural symptoms, balancing the potential benefits against increased mortality and other adverse events is more difficult, but this study provides an important evidence base to inform this decision-making process.”

Rebecca Wood, Chief Executive of the Alzheimer’s Research Trust, said:

“These results are deeply troubling and highlight the urgent need to develop better treatments. 700,000 people are affected by dementia in the UK, a figure that will double in the next 30 years. The Government needs to make Alzheimer’s research funding a priority.

“Only 11 is spent on UK research into Alzheimer's for every person affected by the disease, compared to 289 for cancer patients.”

Janet Carter, from West Yorkshire, whose parents were both diagnosed with Alzheimer’s, said: “My father died relatively quickly after he was diagnosed with Alzheimer’s and he was prescribed a neuroleptic drug. My mother, who also has Alzheimer’s, is still alive almost a decade after being diagnosed. She was never given these drugs. I don’t know if what happened to my dad is linked to these findings, but either way I’m very shocked by them.”

This is the largest neuroleptic withdrawal study of Alzheimer's patients and the only long-term one of its type.


Story Source:

The above story is based on materials provided by Alzheimer's Research Trust. Note: Materials may be edited for content and length.


Cite This Page:

Alzheimer's Research Trust. "Alzheimer's Patients Are Dying Early Because Of Controversial Drugs." ScienceDaily. ScienceDaily, 31 March 2007. <www.sciencedaily.com/releases/2007/03/070330230946.htm>.
Alzheimer's Research Trust. (2007, March 31). Alzheimer's Patients Are Dying Early Because Of Controversial Drugs. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2007/03/070330230946.htm
Alzheimer's Research Trust. "Alzheimer's Patients Are Dying Early Because Of Controversial Drugs." ScienceDaily. www.sciencedaily.com/releases/2007/03/070330230946.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins