Featured Research

from universities, journals, and other organizations

Drug Reduces Daily 'Off' Time For Parkinson Patients

Date:
April 3, 2007
Source:
American Academy of Neurology
Summary:
Parkinson disease patients taking the drug, ropinirole 24-hour prolonged release significantly reduced their daily "off" time in which Parkinson's symptoms like tremor, slowness, stiffness and walking difficulty return as drugs wear off, according to a recent study.

Parkinson disease patients taking the drug, ropinirole 24-hour prolonged release significantly reduced their daily "off" time in which Parkinson's symptoms like tremor, slowness, stiffness, and walking difficulty return as drugs wear off, according to a study published in the April 3, 2007, issue of Neurology®, the scientific journal of the American Academy of Neurology.

Related Articles


The study involved 393 people with Parkinson disease who weren't responding optimally to the widely used treatment for Parkinson, levodopa. For the study, half of the group took the prolonged release version of the drug ropinirole, called ropinirole 24-hour, and levodopa for six months. The other half took placebo and levodopa. Other Parkinson disease medications were not changed during the study.

Researchers found those people taking the drug reduced their average daily "off" time by 2.1 hours compared to .3 hours in the placebo group.

"Ropinirole 24-hour prolonged release, when taken with levodopa, is effective in reducing daily 'off' time for Parkinson patients who aren't getting the best results from levodopa," said study author Rajesh Pahwa, MD, with the University of Kansas Medical Center in Kansas City, Kansas, and Fellow of the American Academy of Neurology. "We also found the drug helped improve quality of life and motor function."

Among those taking ropinirole, researchers found significant improvements in troublesome Parkinson symptoms, quality of life, depression, emotional well-being, stigma, and sleep. Over half of the people in the ropinirole group were classified as much improved" or "very much improved" compared to 14 percent in the placebo group. Those taking ropinirole were also able to reduce their dosage of levodopa.

According to the study, common side effects were involuntary movements, nausea, dizziness, drowsiness, hallucinations, and sudden drops in blood pressure. The 24-hour prolonged release ropinirole appears to be as effective as immediate release ropinirole and better tolerated.

The study was supported by GlaxoSmithKline and Skye Pharma, makers of prolonged release ropinirole.


Story Source:

The above story is based on materials provided by American Academy of Neurology. Note: Materials may be edited for content and length.


Cite This Page:

American Academy of Neurology. "Drug Reduces Daily 'Off' Time For Parkinson Patients." ScienceDaily. ScienceDaily, 3 April 2007. <www.sciencedaily.com/releases/2007/04/070402162129.htm>.
American Academy of Neurology. (2007, April 3). Drug Reduces Daily 'Off' Time For Parkinson Patients. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2007/04/070402162129.htm
American Academy of Neurology. "Drug Reduces Daily 'Off' Time For Parkinson Patients." ScienceDaily. www.sciencedaily.com/releases/2007/04/070402162129.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins